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2-Nitro-p-Phenylenediamine
AKA “2-Nitro-4-phenylenediamine, RefChem:88700, 4-diamine, 4-phenylenediamine, 4-Diamino-2-nitrobenzene, 4-Benzenediamine, 5-Diaminonitrobenzene, 4-benzenediamine”
Synthetic
Ingredient Facts
2-Nitro-p-Phenylenediamine
AKA: 2-Nitro-4-phenylenediamine, RefChem:88700, 4-diamine, 4-phenylenediamine, 4-Diamino-2-nitrobenzene, 4-Benzenediamine, 5-Diaminonitrobenzene, 4-benzenediamine
Synthetic · Hair Dyeing · EWG: 6
Synthetic
Synthetic
Clean
A synthetic color ingredient that creates deep, lasting hair dye shades. It's commonly used in permanent hair coloring formulas to deliver rich, vibrant color that resists fading.
Solubility less than 1 mg/mL at 72 °F (NTP, 1992)
Formula
C6H7N3O2
Mol. Weight
153.14
CAS #
5307-14-2
Form
Liquid
State
Almost black needles with dark-green luster or black powder. (NTP, 1992)
See origin →
Functions
Hair Dyeing
Antioxidant Protection
Reduces Inflammation
Fights Bacteria
Colors Hair
Traditional Use
A synthetic hair dye ingredient developed in the early-to-mid 20th century. Created to replace earlier, less stable dye precursors and produce permanent hair color.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
No
Allergen Warning
⚠️ PPD (Hair Dye)
EWG
6
CIR
Insufficient
Pregnancy
No
CIR Safety Findings
Not a Sensitizer
ewg-6
medical-approval
all-shades-safe
Regulatory Status
USAunder review
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Final Report on the Safety Assessment of 2-Nitro-p-Phenylenediamine and 4-Nitro-o-Phenylenediamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
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Final Report on the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate, and Toluene-3,4-Diamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
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Tentative Report: Amended Safety Assessment of 2-Nitro-p-Phenylenediamine as used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
2-Nitro-p-Phenylenediamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Percutaneous absorption of 2-nitro-p-phenylenediamine.
Howes D, Black JG
International journal of cosmetic science, 1983
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Teratogenic evaluation of 2-nitro-p-phenylenediamine, 4-nitro-o-phenylenediamine, and 2,5-toluenediamine sulfate in the mouse.
Marks TA, Gupta BN, Ledoux TA, Staples RE
Teratology, 1981
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Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR