2,4-Diaminophenoxyethanol HCl
AKA “4-Diaminophenoxyethanol dihydrochloride, RefChem:1059692, Ethanol, dihydrochloride, 4-DIAMINOPHENOXYETHANOL HYDROCHLORIDE
Synthetic
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Ingredient Facts
2,4-diaminophenoxyethanol hcl
AKA: 4-Diaminophenoxyethanol dihydrochloride, RefChem:1059692, Dihydrochloride, 4-DIAMINOPHENOXYETHANOL HYDROCHLORIDE
Synthetic · Hair Dyeing · EWG: 6
Plant-Derived
Synthetic
Clean
A color-holding ingredient that helps hair dyes develop and stay vibrant on strands.
Formula
C8H13ClN2O2
Mol. Weight
204.65
CAS #
66422-95-5
Form
Liquid
Plant-Derived
Synthetic. Synthesized from phenylenediamine compounds and ethylene oxide derivatives through organic synthesis methods. Produced via nucleophilic substitution and hydrogenation reactions to form the stable hydrochloride salt.
Function
Hair Dyeing
Benefits
Colors Hair
Traditional Use
A hydrochloride form of a synthetic hair dye precursor developed for oxidative hair coloring. It was designed to improve water solubility and stability in alkaline permanent wave solutions.
Skin Types
all-skin-types
Best For
Target
General
Melanin-Rich Skin
Suitable
Pregnancy Safe
No
EWG Score6
CIR Safety Findings
ewg-6, medical-approval, all-shades-safe, Not a Sensitizer
Regulatory Status
USApermitted
EUpermitted
JAPANpermitted
CANADApermitted
Safety review of phenoxyethanol when used as a preservati...
B Dréno, T Zuberbier, C Gelmetti, G Gontijo, M Marinovich
Journal of the European Academy of Dermatology and Venereology : JEADV, 2019
Safety Assessment of Diethanolamine and Its Salts as Used...
Monice M Fiume, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen + 6 more
International journal of toxicology, 2017
Safety Assessment of Diethanolamine and Its Salts as Used...
Monice M Fiume, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen + 6 more
International journal of toxicology, 2017
Safety Assessment of Diethanolamine and Its Salts as Used...
Monice M Fiume, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen + 6 more
International journal of toxicology, 2017
Phenoxyethanol Safety Assessment
Cosmetic Ingredient Review Expert Panel
International Journal of Toxicology, 2019
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR