4-Nitro-m-Phenylenediamine
AKA “5131-58-8, 4-Nitro-1, 3-phenylenediamine, 2, 4-Diaminonitrobenzene, 4-NITRO-1, 3-BENZENEDIAMINE, 1, 3-Benzenediamine, 4-nitro-, 3-Diamino-4-nitrobenzene, 3-diaminobenzene, m-Phenylenediamine, C.I. 76030”
Ingredient
Ingredient Facts
4-Nitro-m-Phenylenediamine
AKA: 5131-58-8, 4-Nitro-1, 3-phenylenediamine, 2, 4-Diaminonitrobenzene, 4-NITRO-1, 3-BENZENEDIAMINE, 1, 3-Benzenediamine, 3-Diamino-4-nitrobenzene, 3-diaminobenzene, C.I. 76030
Ingredient · Hair Dyeing · EWG: 3
Synthetic
Not Clean
4-nitro-m-phenylenediamine (CI 76030)
Solubility less than 1 mg/mL at 68.9 °F (NTP, 1992)
Formula
C6H7N3O2
Mol. Weight
153.14
CAS #
5131-58-8
Form
Liquid
State
4-nitro-1,3-benzenediamine appears as orange prisms with blue luster or yellow crystalline solid. (NTP, 1992)
See origin →
Functions
Hair Dyeing
Colors Hair
Traditional Use
A synthetic hair dye ingredient developed in the early 20th century. One of the key components in permanent hair coloring chemistry, designed to replace earlier plant-based colorants like indigo and henna.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
No
Final Report on the Safety Assessment of 2-Nitro-p-Phenylenediamine and 4-Nitro-o-Phenylenediamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 4-Methoxy-m-Phenylenediamine, 4-Methoxy-m-Phenylenediamine Sulfate, and 4-Methoxy-m-Phenylenediamine-HCI
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 4-Nitro-m-Phenylenediamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of m-Phenylenediamine and m-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Amended Safety Assessment of 4-Nitro-o-Phenylenediamine as used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
4-Nitro-o-Phenylenediamine
European Commission
EU Cosmetic Ingredient Database (CosIng)
2-Methyl-m-phenylenediamine
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-Ethoxy-m-phenylenediamine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-Methoxy-m-phenylenediamine and its sulfate salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-Methoxy-m-phenylenediamine-HCl
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-Methyl-m-phenylenediamine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Teratogenic evaluation of 2-nitro-p-phenylenediamine, 4-nitro-o-phenylenediamine, and 2,5-toluenediamine sulfate in the mouse.
Marks TA, Gupta BN, Ledoux TA, Staples RE
Teratology, 1981
Mutagenicity of a new hair dye ingredient: 4-ethoxy-m-phenylenediamine.
Prival MJ, Mitchell VD, Gomez YP
Science (New York, N.Y.), 1980
Phenazine derivatives as the mutagenic reaction product from o- or m-phenylenediamine derivatives with hydrogen peroxide.
Watanabe T, Hirayama T, Fukui S
Mutation research, 1989
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR