6-Hydroxyindole
AKA “
2380-86-1, 1H-indol-6-ol, IMEXINE OBA, 3I03JZ599T, DTXSID20178497, RefChem:104788, DTXCID50100988, 417-020-4, 6-indolol
”
Ingredient
🦆
❤️
👻
Ingredient Facts
6-Hydroxyindole
AKA: 2380-86-1, 1H-indol-6-ol, IMEXINE OBA, 3I03JZ599T, DTXSID20178497, RefChem:104788, DTXCID50100988, 417-020-4, 6-indolol
Ingredient · Hair Dyeing · EWG: 7
WHAT IS IT?
Synthetic
Not Clean
structure in first source
Formula
C8H7NO
Mol. Weight
133.15
CAS #
2380-86-1
Form
Powder
See origin →
WHAT'S IT DO?
Functions
Hair Dyeing
Colors Hair
Traditional Use
Synthetic precursor compound developed for hair coloring applications in the 20th century, used in oxidative hair color systems as a color-generating intermediate.
Skin Types
●
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
IS IT SAFE?
EWG
7
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not an Irritant
ewg-7
medical-approval
all-shades-safe
Regulatory Status
USA
✔ permitted
EU
✔ permitted
JAPAN
✔ permitted
CANADA
✔ permitted
Regulatory Agencies
EWG
CIR
FDA
EU COSING
Health Canada
🧂
Conflict of interest.
WHAT'S THE PROOF?
Safety assessment of 6-hydroxyindole as used in cosmetics.
Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA et al.
International journal of toxicology, 2014
→
Safety Assessment of 6-Hydroxyindole as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
6-Hydroxyindole
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
6-Hydroxyindole
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Verified Jun 2026
· 🧪 = conflict
Data: PubChem · CosIng · EWG · CIR