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Acetyl Hexapeptide-8 Amide
AKA “Acetyl hexapeptide-3, Acetyl Hexapeptide-8, Argireline NP, Hexapeptide 3, Acetyl hexapeptide 3”
Skin Conditioning
Ingredient Facts
Acetyl hexapeptide-8 amide
AKA: Acetyl hexapeptide-3, Argireline NP, Hexapeptide 3, Acetyl hexapeptide 3
Skin Conditioning · Skin Conditioning · EWG: 4
Synthetic
Skin Conditioner
Not Clean
Acetyl Hexapeptide-8 Amide is the product obtained by the acetylation of Hexapeptide-8 in which the C-terminus is an amide.
Formula
C35H62N14O11S
Mol. Weight
887.0
CAS #
616204-22-9
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Boosts collagen production
Reduces fine lines
Traditional Use
Developed in the 1990s as a synthetic peptide designed to mimic the effects of botulinum toxin by relaxing facial muscles, marketed as a topical anti-wrinkle alternative.
Skin Types
●all-skin-types
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not an Irritant
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR