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Acetyl Proline
AKA “N-Acetyl-L-proline, 1-Acetyl-L-proline, (2S)-1-acetylpyrrolidine-2-carboxylic acid, L-Proline, (S)-1-acetylpyrrolidine-2-carboxylic acid, Proline, (s)-n-acetylproline, (S)-(-)-N-acetylproline”
Synthetic
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Ingredient Facts
Acetyl proline
AKA: N-Acetyl-L-proline, 1-Acetyl-L-proline, (2S)-1-acetylpyrrolidine-2-carboxylic acid, L-Proline, (S)-1-acetylpyrrolidine-2-carboxylic acid, (s)-n-acetylproline, (S)-(-)-N-acetylproline
Synthetic · Skin Conditioning | Humectant | Film Forming · EWG: 4
Plant-Derived
Humectant
Occlusive
Skin Conditioner
Amino Acid
Synthetic
Clean
A gentle amino acid that softens and hydrates skin, leaving it smooth and supple without a heavy feel.
Solubility >23.6 [ug/mL] (The mean of the results at pH 7.4)
Formula
C7H11NO3
Mol. Weight
157.17
CAS #
68-95-1
Form
Powder
Plant-Derived
Synthetic. Acetyl proline is synthesized from proline, a naturally occurring amino acid, through acetylation chemistry. The compound is produced by reacting proline with acetic anhydride or acetyl chloride under controlled conditions.
Function
Skin Conditioning | Humectant | Film Forming
Benefits
Locks In Moisture
Traditional Use
A synthetic acetylated amino acid derivative used in modern skincare formulations. Developed to enhance collagen-related benefits and improve the penetration of amino acid-based skincare products.
Skin Types
all-skin-types
Best For
Target
Wrinkles
Melanin-Rich Skin
Suitable
Pregnancy Safe
Yes
EWG Score4
CIR Safety Findings
medical-approval, all-shades-safe, Not a Sensitizer
Regulatory Status
USAunder review
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR