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Allantoin Biotin
AKA “UNII-8445SU9RKR, 8445SU9RKR, DTXSID30884077, UREA, (2, 5-DIOXO-4-IMIDAZOLIDINYL)-, MONO((3AS, 4S, 6AR)-HEXAHYDRO-2-OXO-1H-THIENO(3, 4-D)IMIDAZOLE-4-PENTANOATE), MONO((3AS-(3A.ALPHA., 4.BETA., 6A.ALPHA.))-HEXAHYDRO-2-OXO-1H-THIENO(3, RefChem:110742, ALLANTOIN BIOTIN [INCI], DTXCID401023548, 1H-THIENO(3, 4-D)IMIDAZOLE-4-PENTANOIC ACID, HEXAHYDRO-2-OXO-, (3AS-(3AALPHA, 4BETA, 6AALPHA))-, COMPD. WITH (2, 5-DIOXO-4-IMIDAZOLIDINYL)UREA (1:1)”
Skin Conditioning
Ingredient Facts
Allantoin biotin
AKA: UNII-8445SU9RKR, 8445SU9RKR, DTXSID30884077, UREA, (2, 5-DIOXO-4-IMIDAZOLIDINYL)-, MONO((3AS, 4S, 6AR)-HEXAHYDRO-2-OXO-1H-THIENO(3, 4-D)IMIDAZOLE-4-PENTANOATE), MONO((3AS-(3A.ALPHA., 4.BETA., 6A.ALPHA.))-HEXAHYDRO-2-OXO-1H-THIENO(3, RefChem:110742, ALLANTOIN BIOTIN [INCI], DTXCID401023548, 1H-THIENO(3, 4-D)IMIDAZOLE-4-PENTANOIC ACID, HEXAHYDRO-2-OXO-, (3AS-(3AALPHA, 4BETA, 6AALPHA))-, COMPD. WITH (2, 5-DIOXO-4-IMIDAZOLIDINYL)UREA (1:1)
Skin Conditioning · Soothing · EWG: 4
Synthetic
Soothing
Skin Conditioner
Barrier Support
B Vitamin
Wound Healer
Not Clean
Urea, (2,5-dioxo-4-imidazolydinyl)-, compound with 2H-thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, [3as-(3aalpha,4b,6aalpha)]-
Formula
C14H22N6O6S
Mol. Weight
402.43
CAS #
4492-73-3
Form
Powder
See origin →
Functions
Anti-Sebum
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Soothing
Calms redness, irritation, and inflammation. Your skin's chill pill — great for sensitive, reactive, or post-procedure skin.
Nourishing
Protecting
Traditional Use
A synthetic complex combining allantoin (traditional comfrey derivative used for skin healing) with biotin (vitamin B7, discovered in the 1930s). Developed in modern cosmetics to enhance skin conditioning and strengthen barrier function.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Dermal Absorption 10%
Concentration Guide
Dermal absorption: 10%. Source: CIR Safety Assessment (CIR Seq 310).
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Safety Assessment of Hydroxyethyl Urea as Used in Cosmetics.
Akinsulie A, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2024
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Topical urea in skincare: A review.
Leonardo Celleno
Dermatologic therapy, 2018
→
Topical urea in skincare: A review.
Leonardo Celleno
Dermatologic therapy, 2018
→
Topical urea in skincare: A review.
Leonardo Celleno
Dermatologic therapy, 2018
→
Topical urea in skincare: A review.
Celleno L
Dermatologic therapy, 2018
→
Final Report of the Safety Assessment for Imidazolidinyl Urea
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Diazolidinyl Urea
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Polyoxymethylene Urea
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Urea
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Imidazolidinyl Urea
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Hydroxyethyl Urea As Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Scientific Literature Review: Safety Assessment of Centaurea cyanus Flower-Derived Ingredients as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Allantoin Biotin
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diazolidinyl Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Echinacea Purpurea (echinacea) flower/leaf/stem Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Echinacea Purpurea Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethyl Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Imidazolidinyl Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Polyoxymethylene Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Influence of excipients on moisturizing effect of urea.
Couteau C, Coiffard LJ, Sébille-Rivain V
Drug development and industrial pharmacy, 2006
→
Diazolidinyl Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxyethyl Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Imidazolidinyl Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Polyoxymethylene Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
1-Butyl-3-(N-crotonoylsulfanilyl) urea
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Claviceps purpurea Tul., its alkaloids and galenical preparations
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Digitalis purpurea L., all heterosides of
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Thiourea and its derivatives
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Urea
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Urea (carbamide) peroxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Recombinant scFv-Fc Anti-kallikrein 7 Antibody-Loaded Thermosensitive Hydrogels Against Skin Desquamation Disorders.
Laureano AFS, Vigato AA, Puzer L, de Araujo DR
ACS applied bio materials, 2024
→
Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs.
Sanz MT, Campos C, Milani M, Foyaca M, Lamy A et al.
Journal of cosmetic dermatology, 2016
→
Safety assessment of diammonium phosphate and urea used in the manufacture of cigarettes.
Stavanja MS, Curtin GM, Ayres PH, Bombick ER, Borgerding MF et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2008
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR