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Allantoin Glycyrrhetinic Acid
AKA “H6FL381368, UNII-H6FL381368, 4572-09-2, ALLANTOIN, MONO(3.BETA.-HYDROXY-11-OXOOLEAN-12-EN-30-OATE), UREA, (2, 5-DIOXO-4-IMIDAZOLIDINYL)-, MONO((3.BETA., 20.BETA.)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OATE), RefChem:110745, ALLANTOIN GLYCYRRHETINIC ACID [INCI], MONO(3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OATE), OLEAN-12-EN-30-OIC ACID, 3BETA-HYDROXY-11-OXO-, COMPD. WITH ALLANTOIN”
Acid
Ingredient Facts
Allantoin glycyrrhetinic acid
AKA: H6FL381368, UNII-H6FL381368, 4572-09-2, MONO(3.BETA.-HYDROXY-11-OXOOLEAN-12-EN-30-OATE), UREA, (2, 5-DIOXO-4-IMIDAZOLIDINYL)-, MONO((3.BETA., 20.BETA.)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OATE), RefChem:110745, ALLANTOIN GLYCYRRHETINIC ACID [INCI], MONO(3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OATE), OLEAN-12-EN-30-OIC ACID, 3BETA-HYDROXY-11-OXO-, COMPD. WITH ALLANTOIN
Acid · Soothing · EWG: 1
Synthetic
Soothing
Barrier Support
Wound Healer
Acid
Clean
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta., 20.beta.)-, compound with (2,5-dioxo-4-imidazolydinyl)urea (1:1)
Formula
C34H52N4O7
Mol. Weight
628.80
CAS #
4572-09-2
Form
Liquid
State
Solid
See origin →
Functions
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Soothing
Calms redness, irritation, and inflammation. Your skin's chill pill — great for sensitive, reactive, or post-procedure skin.
Nourishing
Protecting
Traditional Use
Combines allantoin (traditional comfrey derivative for skin healing) with glycyrrhetinic acid (the active compound from licorice root, used for centuries in Ayurvedic and Chinese medicine for inflammation). Developed to maximize soothing and conditioning benefits.
Skin Types
●all-skin-types, gentle
Best For
Redness
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not an Irritant
ewg-1
medical-approval
pregnancy-nursing-safe
all-shades-safe
Concentration Guide
2%
0%3%
Reg. Limit
FDA OTC limit: 2% (Skin Protectant). Source: FDA OTC Monograph, 21 CFR 347.10. Dermal absorption: 10%. Source: CIR Safety Assessment (CIR Seq 310).
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
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Safety Assessment of Hydroxyethyl Urea as Used in Cosmetics.
Akinsulie A, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2024
→
Final report of the safety assessment of allantoin and its related complexes.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2010
→
Final report of the safety assessment of allantoin and its related complexes.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2010
→
Final report of the safety assessment of allantoin and its related complexes.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2010
→
Final report of the safety assessment of allantoin and its related complexes.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2010
→
Topical urea in skincare: A review.
Leonardo Celleno
Dermatologic therapy, 2018
→
Topical urea in skincare: A review.
Leonardo Celleno
Dermatologic therapy, 2018
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Topical urea in skincare: A review.
Leonardo Celleno
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Topical urea in skincare: A review.
Celleno L
Dermatologic therapy, 2018
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Final Report of the Safety Assessment for Imidazolidinyl Urea
Cosmetic Ingredient Review (CIR) Expert Panel
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Final Report of the Safety Assessment of Allantoin and its Related Complexes
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Final Report on the Safety Assessment of Diazolidinyl Urea
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Final Report on the Safety Assessment of Urea
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Imidazolidinyl Urea
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Safety Assessment of Hydroxyethyl Urea As Used in Cosmetics
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Allantoin
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EU Cosmetic Ingredient Database (CosIng)
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Hydroxyethyl Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Imidazolidinyl Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Polyoxymethylene Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Influence of excipients on moisturizing effect of urea.
Couteau C, Coiffard LJ, Sébille-Rivain V
Drug development and industrial pharmacy, 2006
→
Allantoin
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EWG Skin Deep Cosmetics Database
→
Allantoin Glycyrrhetinic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Allantoin Panthenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diazolidinyl Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxyethyl Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Imidazolidinyl Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Polyoxymethylene Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Urea
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EWG Skin Deep Cosmetics Database
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Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR