Aminomethyl Propanediol
AKA “2-Amino-2-methyl-1, 3-propanediol, 115-69-5, 2-Amino-2-methylpropane-1, 3-diol, AMPD, Aminoglycol, Gentimon, 1, 3-Propanediol, 2-amino-2-methyl-, Isobutandiol-2-amine, 1-Di(hydroxymethyl)ethylamine”
Synthetic
Ingredient Facts
Aminomethyl propanediol
AKA: 2-Amino-2-methyl-1, 3-propanediol, 115-69-5, 2-Amino-2-methylpropane-1, 3-diol, AMPD, Aminoglycol, Gentimon, 1, 3-Propanediol, 2-amino-2-methyl-, Isobutandiol-2-amine, 1-Di(hydroxymethyl)ethylamine
Synthetic · Humectant · EWG: 1
Synthetic
Humectant
Solvent
Synthetic
Clean
2-amino-2-methylpropane-1,3-diol is an aminodiol that is propane-1,3-diol substituted ny an amino and a methyl group at position 2.
Formula
C4H11NO2
Mol. Weight
105.14
CAS #
115-69-5
Form
Liquid
State
Pellets or Large Crystals, Liquid
See origin →
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Buffering
Provides scent
Maintains optimal pH
Traditional Use
A modern synthetic humectant developed in the late 20th century as an alternative to glycerin and propylene glycol. Created to provide hydration benefits while offering improved stability and sensory profile in cosmetic formulations.
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
Safety Assessment of Tromethamine, Aminomethyl Propanediol, and Aminoethyl Propanediol as Used in Cosmetics.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2018
Safety Assessment of Tromethamine, Aminomethyl Propanediol, and Aminoethyl Propanediol as Used in Cosmetics.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2018
Final amended report on safety assessment on aminomethyl propanol and aminomethyl propanediol.
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Addendum to the Final Report on the Safety Assessment of 2-Bromo-2-Nitropropane-1,3-Diol (JEPT 4(4) 47-61 1980)
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Amended Report on the Safety Assessment of Aminomethyl Propanol and Aminomethyl Propanediol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report of the Safety Assessment for 2-Bromo-2-Nitropropane-1,3-Diol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Revised Tentative Report: Amended Safety Assessment of 2-Bromo-2-Nitropropane-1,3-Diol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Safety Assessment of Tromethamine, Aminomethyl Propanediol and Aminoethyl Propanediol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
2-Bromo-2-Nitropropane-1,3-Diol
European Commission
EU Cosmetic Ingredient Database (CosIng)
2-Bromo-2-Nitropropane-1,3-Diol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Aminomethyl Propanediol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2-Bromo-2-nitropropane-1,3-diol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Progress in 1,3-propanediol biosynthesis.
Li B, Gao W, Pan Y, Yao Y, Liu G
Frontiers in bioengineering and biotechnology, 2024
Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function.
Pinto JR, Monteiro E Silva SA, Leonardi GR
International journal of cosmetic science, 2024
Kitty Litter Dermatitis from-Bromo-2-Nitropropane-1,3-Diol.
Sullenbarger JW, Hensley B, Travers JB
Skinmed, 2017
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR