Ammonium Glycyrrhizate
AKA “AMMONIUM GLYCYRRHIZINATE, 53956-04-0, Monoammonium glycyrrhizinate, Glycamil, Glycyrram, Monoammonium glycyrrhizate, Ammoniated glycyrrhizin, Glycyrrhizic acid, ammonium salt, monoammonium salt”
Skin Conditioning
Ingredient Facts
Ammonium glycyrrhizate
AKA: AMMONIUM GLYCYRRHIZINATE, 53956-04-0, Monoammonium glycyrrhizinate, Glycamil, Glycyrram, Monoammonium glycyrrhizate, Ammoniated glycyrrhizin, Glycyrrhizic acid, Ammonium salt, Monoammonium salt
Skin Conditioning · Skin Conditioning · EWG: 1
Synthetic
Skin Conditioner
Clean
Monoammonium glycyrrhizinate is an organic molecular entity.
Formula
C42H65NO16
Mol. Weight
840.00
CAS #
53956-04-0
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Brightens uneven skin tone
Evens pigmentation
Quells irritation
Traditional Use
Extracted from licorice root (Glycyrrhiza glabra), which has been used for thousands of years in Traditional Chinese Medicine and Ayurveda for skin inflammation and soothing. The ammonium salt form was developed in modern cosmetics to stabilize and enhance licorice's anti-inflammatory benefits.
Skin Types
●all-skin-types, gentle
Best For
Irritation
Pregnancy & Breastfeeding Safe
Yes
Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery.
Barone A, Cristiano MC, Cilurzo F, Locatelli M, Iannotta D et al.
Colloids and surfaces. B, Biointerfaces, 2020
Final Report on the Safety Assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammon
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Ammonium Glycyrrhizate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Glycyrrhizic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
Ammonium Glycyrrhizate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Furfuryltrimethyl ammonium salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi.
Li J, Chaytor JL, Findlay B, McMullen LM, Smith DC et al.
Journal of agricultural and food chemistry, 2015
Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi.
Li J, Chaytor JL, Findlay B, McMullen LM, Smith DC et al.
Journal of agricultural and food chemistry, 2015
Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi.
Li J, Chaytor JL, Findlay B, McMullen LM, Smith DC et al.
Journal of agricultural and food chemistry, 2015
Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi.
Li J, Chaytor JL, Findlay B, McMullen LM, Smith DC et al.
Journal of agricultural and food chemistry, 2015
Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides.
Wang Z, Liu J, Chen Q, Wu Y, Li Y et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025
Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides.
Wang Z, Liu J, Chen Q, Wu Y, Li Y et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR