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anhydroxylitol
AKA “4-Anhydro-D-xylitol, (2R, 4S)-2-(Hydroxymethyl)tetrahydrofuran-3, 4-Anhydroxylitol, D-Xylitol, Xylitol”
Humectant
Ingredient Facts
anhydroxylitol
AKA: 4-Anhydro-D-xylitol, (2R, 4S)-2-(Hydroxymethyl)tetrahydrofuran-3, 4-Anhydroxylitol, D-Xylitol
Humectant · Humectant · EWG: 1
Synthetic
Humectant
Skin Conditioner
Clean
D-Xylitol, 1,4-Anhydro-
Formula
C5H10O4
Mol. Weight
134.13
CAS #
53448-53-6
Form
Liquid
See origin →
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks In Moisture
Traditional Use
A sugar alcohol developed in the late 20th century as a humectant and sweetening agent in modern cosmetics. It was synthesized to provide moisturizing benefits similar to glycerin while being suitable for formulation in various skincare products.
Skin Types
●all-skin-types, gentle
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
ewg-1
medical-approval
pregnancy-nursing-safe
all-shades-safe
Phototoxicity Concern
Concentration Guide
Dermal absorption: 100%. Source: CIR Safety Assessment (CIR Seq 815).
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Are sodium lauryl sulfate-containing toothpastes suitable vehicles for xylitol?
Assev S, Wåler SM, Rølla G
European journal of oral sciences, 1997
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Are sodium lauryl sulfate-containing toothpastes suitable vehicles for xylitol?
Assev S, Wåler SM, Rølla G
European journal of oral sciences, 1997
→
Safety Assessment of Mannitol, Sorbitol, and Xylitol as U...
Priya Cherian, Wilma F Bergfeld, Donald V Belsito, Curtis D Klaassen, Daniel C Liebler, James G Marks + 6 more
International journal of toxicology, 2025
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Safety Assessment of Anhydrogalactose,Anhydroglucitol, Anhydroxylitol, Arabinose,Psicose, Saccharide Hydrolysate, andSaccharide Isomerate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
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Safety Assessment of Mannitol, Sorbitol and Xylitol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
anhydroxylitol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
xylitol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
anhydroxylitol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
xylitol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Safety Assessment of Anhydrogalactose, Anhydroglucitol, Anhydroxylitol, Arabinose, Psicose, Saccharide Hydrolysate, and Saccharide Isomerate as Used i
Johnson W Jr, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
Safety Assessment of Anhydrogalactose, Anhydroglucitol, Anhydroxylitol, Arabinose, Psicose, Saccharide Hydrolysate, and Saccharide Isomerate as Used i
Johnson W Jr, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
Effects of Xylitol-laced Sweets on the Accumulation of Dental Plaque : A Systematic Review and Meta-Analysis.
Mostafazadehbakhtiyary M, Majidinia S, Sohouli M, Chalakinia H, Langari AS et al.
International dental journal, 2025
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Sweeteners: erythritol, xylitol and cardiovascular risk-friend or foe?
Wölnerhanssen BK, Meyer-Gerspach AC, Arduini A, D'Alessandro A, Gronda E et al.
Cardiovascular research, 2025
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR