Benzalkonium Chloride
AKA “pentonium, Alpagelle, Zephiran, Benzalkonii chloridum, Cloruro de benzalconio, Chlorure de benzalkonium, NSC-758480, CHEBI:3020, Fundamentals, Greenberry
Preservative
Ingredient Facts
Benzalkonium chloride
AKA: Pentonium, Alpagelle, Zephiran, Benzalkonii chloridum, Cloruro de benzalconio, Chlorure de benzalkonium, NSC-758480, CHEBI:3020, Fundamentals, Greenberry
Preservative · Antimicrobial · EWG: 6
Synthetic
Preservative
Cleanser
Not Clean
Benzalkonium Chloride is a mixture of alkylbenzyldimethylammonium chlorides that conforms generally to the formula:
Solubility Very soluble in alcohol, acetone; slightly soluble in benzene; almost insoluble in ether
Formula
C22H40ClN
Mol. Weight
354.00
CAS #
63449-41-2, 68391-01-5, 68424-85-1, 85409-22-9
Form
Liquid
State
White or yellowish-white, amorphous powder or gelatinous pieces; [HSDB]
See origin →
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Antistatic
Deodorant
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Dispersing
Fights Bacteria
Traditional Use
A quaternary ammonium compound synthesized in the early 20th century as a broad-spectrum antimicrobial preservative. Widely adopted by the cosmetics industry in the 1930s-1940s as a replacement for less stable natural preservatives.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
6
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
ewg-6
medical-approval
all-shades-safe
Phototoxicity Concern
Concentration Guide
3%
0%4%
Reg. Limit
EU regulatory limit: 3%. Avoid contact with the eyes Source: EU Cosmetics Regulation (EC) 1223/2009, Annex III (Restricted Substances), Entry 65.
Regulatory Status
USApermitted
EUpermitted
JAPANpermitted
CANADApermitted
Benzalkonium Chloride.
, 2006
Benzalkonium Chloride.
, 2006
Final Report on the Safety Assessment of Benzalkonium Chloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Benzalkonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
Benzalkonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
b) As a conditioning agent in rinse-off hair care products, (i.e. benzalkonium chloride with chain lengths ≥ 16 C).
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Benzalkonium chloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Xanthan gum in aqueous solutions: Fundamentals and applications.
Nsengiyumva EM, Alexandridis P
International journal of biological macromolecules, 2022
Cyclodextrin glucanotransferase: fundamentals and biotechnological implications.
Pardhi DS, Rabadiya KJ, Panchal RR, Raval VH, Joshi RG et al.
Applied microbiology and biotechnology, 2023
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR