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Bis(Tripeptide-1) Copper Acetate
AKA “Prezatide copper acetate, Iamin, PC1020 acetate, A3LEI4P1NB, PC-1020 ACETATE, DTXSID00156359, PC-1020, prezatidi cuprici acetas, RefChem:175996”
Skin Conditioning
Ingredient Facts
Bis (Tripeptide-1) copper acetate
AKA: Prezatide copper acetate, Iamin, PC1020 acetate, A3LEI4P1NB, PC-1020 ACETATE, DTXSID00156359, PC-1020, Prezatidi cuprici acetas, RefChem:175996
Skin Conditioning · Skin Conditioning · EWG: 4
Synthetic
Skin Conditioner
Not Clean
Cuprate (1-), (glycyl-L-histidyl-N1-L-lysinato)[glycyl-N-L-histidyl-N,N3-L-lysinato(2-)]-, hydrogen, diacetate
Formula
C32H54CuN12O12
Mol. Weight
862.40
CAS #
130120-57-9
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Boosts collagen production
Reduces fine lines
Traditional Use
A synthetic peptide compound developed in recent decades for skincare products. Designed to provide skin-firming and anti-aging benefits, mimicking or enhancing the effects of copper peptides used in modern cosmetic science.
Skin Types
●all-skin-types
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Safety Assessment of Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl as Used in Cosmetics.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2016
→
Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosmetics.
Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2022
→
Evaluation of the teratological and dominant lethal potential of N,N-bis-(2-hydroxyethyl)-p-phenylenediamine sulphate in a 6-month feeding study in ra
Burnett CM, Re TA, Loehr RF, Rodriguez SC, Corbett JF
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1986
→
Final Amended Report of the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate and Toluene-3,5-Diamine as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Amended Report on the Safety Assessment of 2,4-Diaminophenoxyethanol HCl and 2,4-Diaminophenoxyethanol Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Amended Report on the Safety Assessment of p-Phenylenediamine, p-Phenylenediamine HCl and p-Phenlyenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2-Chloro-p-Phenylenediamine and 2-Chloro-p-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2-Nitro-p-Phenylenediamine and 4-Nitro-o-Phenylenediamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2,4-Diaminophenol and 2,4-Diaminophenol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2,4-Diaminophenoxyethanol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 4-Methoxy-m-Phenylenediamine, 4-Methoxy-m-Phenylenediamine Sulfate, and 4-Methoxy-m-Phenylenediamine-HCI
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 4-Nitro-m-Phenylenediamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of m-Phenylenediamine and m-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of N-Phenyl-p-Phenylenediamine, N-Phenyl-p-Phenylenediamine Hydrochloride, and N-Phenyl-p-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of N,N-Bis(Hydroxyethyl)-p-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of p-Phenylenediamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate, and Toluene-3,4-Diamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Amended Safety Assessment of 2,4-Diaminophenoxyethanol HCl and 2,4-Diaminophenoxyethanol Sulfate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Amended Safety Assessment of 4-Nitro-o-Phenylenediamine as used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Amended Safety Assessment of p-Phenylenediamine, p-Phenylenediamine HCl and p-Phenylenediamine Sulfate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Safety Assessment of Trisodium Ethylenediamine Disuccinate and Tetrasodium Iminodisuccinate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Re-evaluation: N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosemtics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Tripeptide-1, Hexapeptide-12 Their Metal Salts and Fatty Acid Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Tentative Report: Amended Safety Assessment of 2-Nitro-p-Phenylenediamine as used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
2-Chloro-p-Phenylenediamine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
2-Chloro-p-Phenylenediamine Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
2,4-Diaminophenoxyethanol HCl
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
2,4-Diaminophenoxyethanol Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
4-Nitro-o-Phenylenediamine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Bis(Tripeptide-1) Copper Acetate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Copper Tripeptide-1
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dimethoxysilyl Ethylenediaminopropyl Dimethicone
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Manganese Tripeptide-1
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Myristoyl Tripeptide-1
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
N-Phenyl-p-Phenylenediamine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
N-Phenyl-p-Phenylenediamine HCl
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
N-Phenyl-p-Phenylenediamine Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Palmitoyl Dipeptide-5 Diaminohydroxybutyrate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Tripeptide-1
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium Ethylenediamine Disuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2-Nitro-p-Phenylenediamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2,4-Diaminophenoxyethanol HCl
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2,4-Diaminophenoxyethanol Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Copper Tripeptide-1
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
N-Phenyl-p-Phenylenediamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
N-Phenyl-p-Phenylenediamine Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Palmitoyl Dipeptide-5 Diaminohydroxybutyrate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Palmitoyl Dipeptide5 Diaminohydroxybutyrate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Tripeptide-1
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium Ethylenediamine Disuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Allergic contact dermatitis from 2-chloro-p-phenylenediamine in a cream dye for eyelashes and eyebrows.
Hansson C, Thorneby-Andersson K
Contact dermatitis, 2001
→
1-Methoxy-2,4-diaminobenzene and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
1-Methoxy-2,5-diaminobenzene and their salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
2-Methyl-m-phenylenediamine
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
2,4-Diaminophenylethanol and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
4-Ethoxy-m-phenylenediamine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
4-Methoxy-m-phenylenediamine and its sulfate salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
4-Methoxy-m-phenylenediamine-HCl
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
4-Methyl-m-phenylenediamine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Ethylenediamine
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
o-Phenylenediamine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
p-Phenylenediamine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Percutaneous absorption of 2-nitro-p-phenylenediamine.
Howes D, Black JG
International journal of cosmetic science, 1983
→
Studies on the skin uptake and efflux kinetics of N-phenyl-p-phenylenediamine: an aromatic amine intermediate.
Khanna SK, Tewari P, Joshi A, Singh GB
International journal of cosmetic science, 1987
→
Teratogenic evaluation of 2-nitro-p-phenylenediamine, 4-nitro-o-phenylenediamine, and 2,5-toluenediamine sulfate in the mouse.
Marks TA, Gupta BN, Ledoux TA, Staples RE
Teratology, 1981
→
2,4-Diaminoanisole sulfate.
National Toxicology Program
Report on carcinogens : carcinogen profiles, 2011
→
Mutagenicity of a new hair dye ingredient: 4-ethoxy-m-phenylenediamine.
Prival MJ, Mitchell VD, Gomez YP
Science (New York, N.Y.), 1980
→
Phenazine derivatives as the mutagenic reaction product from o- or m-phenylenediamine derivatives with hydrogen peroxide.
Watanabe T, Hirayama T, Fukui S
Mutation research, 1989
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR