Brucine
AKA “
Brucine sulfate, Brucine sulphate, 4845-99-2, KY7O12XPOQ, Brucine sulfate anhydrous, Brucine sulphate anhydrous, NSC-463, Strychnidin-10-one, 2, 3-dimethoxy-, sulfate (2:1), 10, 11-DIMETHOXYSTRYCHNINE SULFATE, RefChem:1080193
”
Ingredient
🦆
❤️
👻
Ingredient Facts
Brucine
AKA: Brucine sulfate, Brucine sulphate, 4845-99-2, KY7O12XPOQ, Brucine sulfate anhydrous, Brucine sulphate anhydrous, NSC-463, Strychnidin-10-one, 2, 3-dimethoxy-, Sulfate (2:1), 10, 11-DIMETHOXYSTRYCHNINE SULFATE, RefChem:1080193
Ingredient · Denaturant · EWG: 5
WHAT IS IT?
Synthetic
Not Clean
2,3-Dimethoxystrychnidin-10-one Sulfate (2:1)
Formula
C46H54N4O12S
Mol. Weight
887.00
CAS #
4845-99-2
Form
Liquid
State
Off-white powder; [Sigma-Aldrich MSDS]
See origin →
WHAT'S IT DO?
Functions
Denaturant
Makes Alcohol Undrinkable
Reduces Inflammation
Locks In Moisture
Traditional Use
An alkaloid compound extracted from the Strychnos nux-vomica tree, traditionally used in Chinese and Ayurvedic medicine for pain relief and inflammation. Its use in modern cosmetics is minimal and primarily historical.
Skin Types
●
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
No
IS IT SAFE?
EWG
5
CIR
Safe as used
Pregnancy
No
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA
✔ permitted
EU
✔ permitted
JAPAN
✔ permitted
CANADA
✔ permitted
Regulatory Agencies
EWG
CIR
FDA
EU COSING
Health Canada
WHAT'S THE PROOF?
Brucine Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Brucine Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Brucine
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR