Calcium PCA
AKA “Calcium pidolate, Efical, 31377-05-6, 7Y2LVU5EKK, CALCIDONE, DTXSID501019893, RefChem:122896, DTXCID601477759, 250-602-4”
Humectant
Ingredient Facts
Calcium pca
AKA: Calcium pidolate, Efical, 31377-05-6, 7Y2LVU5EKK, CALCIDONE, DTXSID501019893, RefChem:122896, DTXCID601477759, 250-602-4
Humectant · Humectant · EWG: 4
Synthetic
Humectant
Skin Conditioner
Amino Acid
Not Clean
L-Proline, 5-Oxo, Calcium Salt (2:1)
Formula
C10H12CaN2O6
Mol. Weight
296.29
CAS #
31377-05-6
Form
Powder
See origin →
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks In Moisture
Traditional Use
Developed in the 1970s as a synthetic humectant derived from pyroglutamic acid. Used in modern skincare to mimic the skin's natural moisturizing factor and improve hydration.
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
Dermal absorption: 5%. Source: CIR Safety Assessment (CIR Seq 683).
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR