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Cetrimonium Methosulfate
AKA “Hexadecyltrimethylammonium methyl sulphate, 1-Hexadecanaminium, N, N-trimethyl-, methyl sulfate, UNII-277IG2X9QC, CRODAZOSOFT DBQ, EINECS 265-352-1, Ammonium, hexadecyltrimethyl, DTXSID3070173, cetyltrimethylammonium methosulfate, CETYLTRIMETHYLAMMONIUM MESYLATE”
Surfactant
Ingredient Facts
Cetrimonium methosulfate
AKA: Hexadecyltrimethylammonium methyl sulphate, 1-Hexadecanaminium, N-trimethyl-, Methyl sulfate, UNII-277IG2X9QC, CRODAZOSOFT DBQ, EINECS 265-352-1, Ammonium, Hexadecyltrimethyl, DTXSID3070173, Cetyltrimethylammonium methosulfate, CETYLTRIMETHYLAMMONIUM MESYLATE
Surfactant · Antimicrobial · EWG: 3
Synthetic
Preservative
Cleanser
Emulsifier
Skin Conditioner
Hair Care
Not Clean
Hexadecyltrimethylammonium methyl sulphate
Formula
C20H45NO4S
Mol. Weight
395.60
CAS #
65060-02-8
Form
Powder
See origin →
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Antistatic
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Fights Bacteria
Traditional Use
Created as a synthetic conditioning agent for modern cosmetics. Designed to provide antistatic and detangling properties similar to natural conditioning agents.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
3
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
ewg-3
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery.
Barone A, Cristiano MC, Cilurzo F, Locatelli M, Iannotta D et al.
Colloids and surfaces. B, Biointerfaces, 2020
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Safety assessment of ammonium hectorites as used in cosmetics.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2013
→
Safety assessment of ammonium hectorites as used in cosmetics.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2013
→
Safety assessment of ammonium hectorites as used in cosmetics.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2013
→
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Amended Safety Assessment of Tall Oil Acid, Sodium Tallate, Potassium Tallate and Ammonium Tallate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl T
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report of the Safety Assessment of Lithium Stearate, Aluminum Distearate, Aluminum Stearate, Aluminum Tristearate, Ammonium Stearate, Calcium Stearate, Magnesium Stearate, Potassium Stearate, So
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Ammonium and Glyceryl Thioglycolates and Thioglycolic Acid
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Ammonium, Potassium, and Sodium Persulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, HEDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, and Trisod
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Glycolic Acid, Ammonium, Calcium, Potassium, and Sodium Glycolates, Methyl, Ethyl, Propyl, and Butyl Glycolates, and Lactic Acid, Ammonium, Calcium, Potassium,
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Sodium Laureth Sulfate and Ammonium Laureth Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Sodium Lauryl Sulfate and Ammonium Lauryl Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Sodium Sulfite, Potassium Sulfite, Ammonium Sulfite, Sodium Bisulfite, Ammonium Bisulfite, Sodium Metabisulfite, and Potassium Metabisulfite
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Safety Assessment of Ammonia and Ammonium Hydroxide as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Ammonium Hectorites as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Acrylamide/Ammonium Acrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Acrylates/Ammonium Methacrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Acrylates Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Acrylates/Ethylhexyl Acrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Acryloyldimethyltaurate/Laureth-7 Methacrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Acryloyldimethyltaurate/Steareth-25 Methacrylate Crosspolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Acryloyldimethyltaurate/Steareth-8 Methacrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Acryloyldimethyltaurate/Vinyl Formamide Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Acryloyldimethyltaurate/VP Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Alginate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Bicarbonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Bisulfite
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium C12-15 Pareth Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Capryleth Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Carbonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Caseinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Coco-Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Cocomonoglyceride Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Cocoyl Isethionate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Cocoyl Sarcosinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Cumenesulfonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Dinonyl Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Dodecylbenzenesulfonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Glycolate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Glycyrrhizate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Hydrolyzed Collagen
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Hydroxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Isostearate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Lactate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Laureth Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Lauroyl Sarcosinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Lauryl Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Myreth Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Myristyl Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Oleate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Persulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Phosphate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Phosphatidyl Rapeseedate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Polyacrylate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Polyacryloyldimethyl Taurate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Silver Zeolite
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Silver Zinc Aluminum Silicate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Stearate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Styrene/Acrylates Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Styrene/Acrylates/Ethylhexyl Acrylate/Lauryl Acrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Sulfite
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Tallate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Thioglycolate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium VA/Acrylates Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Xylenesulfonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cetrimonium Methosulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diammonium Citrate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diammonium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diammonium Phosphate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Styrene/Acrylates/Ammonium Methacrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Acrylamide/Ammonium Acrylate Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Acrylates/Ammonium Methacrylate Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Acrylates Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Acryloyldimethyltaurate/Steareth-25 Methacrylate Crosspolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Acryloyldimethyltaurate/VP Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Bicarbonate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium C12-15 Pareth Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Cocoyl Isethionate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Glycolate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Glycyrrhizate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Hydroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Lactate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Laureth Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Lauroyl Sarcosinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Lauryl Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Myreth Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Persulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Polyacrylate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Polyacryloyldimethyl Taurate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Stearate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Styrene/Acrylates Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Thioglycolate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cetrimonium Methosulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Styrene/Acrylates/Ammonium Methacrylate Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Decamethylenebis (trimethylammonium) salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Dimethyl sulfate
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Furfuryltrimethyl ammonium salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Poldine methyl sulfate
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Tetrylammonium bromide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi.
Li J, Chaytor JL, Findlay B, McMullen LM, Smith DC et al.
Journal of agricultural and food chemistry, 2015
→
Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi.
Li J, Chaytor JL, Findlay B, McMullen LM, Smith DC et al.
Journal of agricultural and food chemistry, 2015
→
Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi.
Li J, Chaytor JL, Findlay B, McMullen LM, Smith DC et al.
Journal of agricultural and food chemistry, 2015
→
Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi.
Li J, Chaytor JL, Findlay B, McMullen LM, Smith DC et al.
Journal of agricultural and food chemistry, 2015
→
Quaternary Ammonium Compounds and Contact Dermatitis: A Review and Considerations During the COVID-19 Pandemic.
Okeke CAV, Khanna R, Ehrlich A
Clinical, cosmetic and investigational dermatology, 2023
→
Quaternary Ammonium Compounds and Contact Dermatitis: A Review and Considerations During the COVID-19 Pandemic.
Okeke CAV, Khanna R, Ehrlich A
Clinical, cosmetic and investigational dermatology, 2023
→
Final report on the safety assessment of Ammonium, Potassium, and Sodium Persulfate.
Pang S, Fiume MZ
International journal of toxicology, 2001
→
Amended safety assessment of tall oil acid, sodium tallate, potassium tallate, and ammonium tallate.
Robinson V, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Amended safety assessment of tall oil acid, sodium tallate, potassium tallate, and ammonium tallate.
Robinson V, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Amended safety assessment of tall oil acid, sodium tallate, potassium tallate, and ammonium tallate.
Robinson V, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Amended safety assessment of tall oil acid, sodium tallate, potassium tallate, and ammonium tallate.
Robinson V, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Safety assessment of diammonium phosphate and urea used in the manufacture of cigarettes.
Stavanja MS, Curtin GM, Ayres PH, Bombick ER, Borgerding MF et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2008
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR