Cetyl Dimethicone
AKA “Polysiloxanes, cetyl Me, di-Me, RefChem:867008, Hexadecyl-methoxy-methyl-trimethylsilyloxysilane, C21H48O2Si2, SCHEMBL28937041, CMUDPAKFOFFESL-UHFFFAOYSA-N, MFCD08276533, hexadecyl-methoxy-methyl-trimethylsilyloxy-silane”
Emollient
Ingredient Facts
Cetyl dimethicone
AKA: Polysiloxanes, Cetyl Me, Di-Me, RefChem:867008, Hexadecyl-methoxy-methyl-trimethylsilyloxysilane, C21H48O2Si2, SCHEMBL28937041, CMUDPAKFOFFESL-UHFFFAOYSA-N, MFCD08276533, Hexadecyl-methoxy-methyl-trimethylsilyloxy-silane
Emollient · Emollient · EWG: 2
Synthetic
Emollient
Skin Conditioner
Silicone
Clean
Siloxanes and silicones, hexadecyl methyl, dimethyl
Formula
C21H48O2Si2
Mol. Weight
388.80
CAS #
191044-49-2
Form
Liquid
See origin →
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
Traditional Use
Developed in the mid-20th century as a silicone hybrid combining dimethicone with a cetyl (long-chain alcohol) backbone. Used in cosmetics starting in the 1960s as a skin conditioning and smoothing agent.
Skin Types
●all-skin-types, gentle
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
EWG
2
CIR
Safe as used
Pregnancy
Yes
Restricted By
CIR Safety Findings
Not a Sensitizer
ewg-2
medical-approval
pregnancy-nursing-safe
all-shades-safe
Regulatory Agencies
Acetyl Methionine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Cetyl Dimethicone
European Commission
EU Cosmetic Ingredient Database (CosIng)
Cetyl Dimethicone/Bis-Vinyldimethicone Crosspolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
PEG-8 Cetyl Dimethicone
European Commission
EU Cosmetic Ingredient Database (CosIng)
Acetyl Methionine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Cetyl Dimethicone
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Cetyl Dimethicone/Bis-Vinyldimethicone Crosspolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
PEG-8 Cetyl Dimethicone
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Preliminary 1 month stability screening of cosmetic multiple emulsions (W/O/W) prepared using cetyl dimethicone copolyol and Polysorbate 80.
Khan H, Akhtar N, Mahmood T, Jameel A, Mohsin S
International journal of cosmetic science, 2015
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR