Chlorhexidine Diacetate
AKA “Chlorhexidine acetate, 56-95-1, Hibitane diacetate, Chlorohexidine diacetate, 10, 040 Diacetate, Chlorhexidini diacetas, DTXSID7032345, 5908ZUF22Y, NSC-526936
Preservative
Ingredient Facts
Chlorhexidine diacetate
AKA: Chlorhexidine acetate, 56-95-1, Hibitane diacetate, Chlorohexidine diacetate, 10, 040 Diacetate, Chlorhexidini diacetas, DTXSID7032345, 5908ZUF22Y, NSC-526936
Preservative · Antimicrobial · EWG: 5
Synthetic
Preservative
Not Clean
N,N'-bis(4-Chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine di(acetate)
Formula
C26H38Cl2N10O4
Mol. Weight
625.50
CAS #
56-95-1
Form
Powder
State
White odorless solid; [Reference #1] White powder; [Aldrich MSDS]
See origin →
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Oral Care
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Fights Bacteria
Traditional Use
A salt form of chlorhexidine created in the mid-20th century to improve stability and solubility. Used in antimicrobial skincare and personal care products for its enhanced preservative properties.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
5
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
ewg-5
medical-approval
all-shades-safe
Concentration Guide
0.3%
0%0%
Reg. Limit
EU regulatory limit: 0.3%. Source: EU Cosmetics Regulation (EC) 1223/2009, Annex V (Preservatives), Entry 42.
Regulatory Status
USApermitted
EUpermitted
JAPANpermitted
CANADApermitted
Final Report on the Safety Assessment of Chlorhexidine/Chlorhexidine Diacetate/Chlorhexidine Dihydrochloride/Chlorhexidine Digluconate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Note Regarding the Safety Assessment of Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, and Chlorhexidine Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Chlorhexidine Diacetate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Chlorhexidine Diacetate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Can 1% chlorhexidine diacetate and ethanol stabilize resin-dentin bonds?
Manso AP, Grande RH, Bedran-Russo AK, Reis A, Loguercio AD et al.
Dental materials : official publication of the Academy of Dental Materials, 2014
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR