Chlorhexidine Digluconate
AKA “Hibiclens, Chlorhexidine gluconate, Dyna-hex, Bioscrub, Hibistat, Microderm, Periochip, Periogard”
Synthetic
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Ingredient Facts
Chlorhexidine digluconate
AKA: Hibiclens, Chlorhexidine gluconate, Dyna-hex, Bioscrub, Hibistat, Microderm, Periochip, Periogard
Synthetic · Antimicrobial | Oral Care | Preservative · EWG: 4
Plant-Derived
Preservative
Synthetic
Clean
A proven antimicrobial ingredient that helps keep products fresh and clean while supporting oral health formulations.
Formula
C34H54Cl2N10O14
Mol. Weight
897.80
CAS #
18472-51-0
Form
Liquid
Plant-Derived
Synthetic. Synthesized from hexamethylene bis(5-methylisoxazolium) chloride and gluconic acid chemical precursors. Produced through multi-step organic synthesis involving condensation reactions and salt formation processes.
Function
Antimicrobial | Oral Care | Preservative
Benefits
Fights Bacteria
Traditional Use
A gluconate salt of chlorhexidine developed to increase water solubility and antimicrobial efficacy. Widely adopted from the 1970s onward in oral rinses, wound care, and antimicrobial skincare formulations.
Skin Types
all-skin-types
Best For
Target
General
Melanin-Rich Skin
Suitable
Pregnancy Safe
Caution
EWG Score4
CIR Safety Findings
ewg-4, all-shades-safe
Concentration Guide
0.3%
0%0%
Reg. Limit
EU regulatory limit: 0.3%. Source: EU Cosmetics Regulation (EC) 1223/2009, Annex V (Preservatives), Entry 42.
Regulatory Agencies
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR