Chlorhexidine Dihydrochloride
AKA “CHLORHEXIDINE HYDROCHLORIDE, 3697-42-5, Chlorhexidine HCl, Dantroche hibitane, AY-5312, E64XL9U38K, DTXSID7047144, NSC-756679, 2, 4, 11, 13-Tetraazatetradecanediimidamide, N, N''-bis(4-chlorophenyl)-3, 12-diimino-, dihydrochloride”
Preservative
Ingredient Facts
Chlorhexidine dihydrochloride
AKA: CHLORHEXIDINE HYDROCHLORIDE, 3697-42-5, Chlorhexidine HCl, Dantroche hibitane, AY-5312, E64XL9U38K, DTXSID7047144, NSC-756679, 2, 4, 11, 13-Tetraazatetradecanediimidamide, N''-bis(4-chlorophenyl)-3, 12-diimino-
Preservative · Antimicrobial · EWG: 4
Synthetic
Preservative
Not Clean
N,N'-bis(4-Chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride
Formula
C22H32Cl4N10
Mol. Weight
578.40
CAS #
3697-42-5
Form
Powder
See origin →
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Oral Care
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Fights Bacteria
Traditional Use
A hydrochloride salt form of chlorhexidine created for improved chemical stability. Used in cosmetics and personal care as an antimicrobial preservative and active ingredient.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Reviewed by CIR
Pregnancy
Caution
CIR Safety Findings
ewg-4
all-shades-safe
Concentration Guide
0.3%
0%0%
Reg. Limit
EU regulatory limit: 0.3%. Source: EU Cosmetics Regulation (EC) 1223/2009, Annex V (Preservatives), Entry 42.
Regulatory Agencies
Final Report on the Safety Assessment of 2,4-Diaminophenol and 2,4-Diaminophenol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2,4-Diaminophenoxyethanol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Chlorhexidine/Chlorhexidine Diacetate/Chlorhexidine Dihydrochloride/Chlorhexidine Digluconate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Note Regarding the Safety Assessment of Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, and Chlorhexidine Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Chlorhexidine Dihydrochloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
Chlorhexidine Dihydrochloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Chlorhexidine Dihydrochloride Shows Anti-tumor Effects in Desmoid Tumors and Colorectal Cancer.
Shin H, Kim Y, Lee Y, Kim J, Ryu YC et al.
Anticancer research, 2024
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR