Cholecalciferol, 1 Alpha,25 Dihydroxy
AKA “Calcitriol, 25-dihydroxycholecalciferol, Active vitamin D3”
Vitamin D3
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Ingredient Facts
Cholecalciferol, 1 alpha,25 dihydroxy
AKA: Calcitriol, 25-dihydroxycholecalciferol, Active vitamin D3
Vitamin D3 · Skin Conditioning | Soothing · EWG: 1
Plant-Derived
Soothing
Skin Conditioner
Vitamin D3
Clean
Safety Ratings: EWG: 1/10 (Low Hazard)
Formula
C27H44O3
Mol. Weight
416.64
CAS #
32222-06-3
Form
Powder
Plant-Derived
Synthetic. Derived from the vitamin D3 chemical family, synthesized from lanosterol or 7-dehydrocholesterol precursors. Produced through selective hydroxylation at the 1-alpha and 25 positions via chemical synthesis or microbial conversion.
Function
Skin Conditioning | Soothing
Benefits
Antioxidant
Anti-Inflammatory
Antimicrobial
Provides scent
Traditional Use
The active metabolite of vitamin D was first identified in 1937. Its use in skincare developed in the 2000s when research demonstrated its role in skin barrier function, immune regulation, and anti-inflammatory benefits.
Skin Types
all-skin-types, gentle
Best For
Target
General
Melanin-Rich Skin
Suitable
Pregnancy Safe
Caution
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR