Cyclodextrin Hydroxypropyltrimonium Chloride
AKA “Cyclodextrin quaternium, HPT-cyclodextrin chloride
Humectant
Ingredient Facts
Cyclodextrin hydroxypropyltrimonium chloride
AKA: Cyclodextrin quaternium, HPT-cyclodextrin chloride
Humectant · Humectant · EWG: 4
Synthetic
Humectant
Occlusive
Skin Conditioner
Not Clean
Cyclodextrin Hydroxypropyltrimonium Chloride is a cosmetic ingredient used as film forming, humectant, skin conditioning. Assessed as safe by the CIR.
CAS #
-
Form
Powder
See origin →
Functions
Film Forming
Creates a physical seal on skin to lock moisture in and keep irritants out. The "slugging" ingredient — barrier protection.
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Viscosity Controlling
Locks In Moisture
Traditional Use
A modern synthetic derivative of cyclodextrin created in the late 20th century. Designed as a conditioning and film-forming agent for hair and skincare products, combining cyclodextrin's delivery properties with quaternary ammonium chemistry for enhanced conditioning.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
Dermal absorption: 2%. Source: CIR Safety Assessment (CIR Seq 680).
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Verified Jun 2026
Data: CosIng · EWG · CIR