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Denatonium Benzoate
AKA “3734-33-6, Bitrex, Lidocaine benzyl benzoate, Aversion, THS-839, Anispray, Gori, Benzoato de denatonio, Benzoate de denatonium”
Ingredient
Ingredient Facts
Denatonium benzoate
AKA: 3734-33-6, Bitrex, Lidocaine benzyl benzoate, Aversion, THS-839, Anispray, Gori, Benzoato de denatonio, Benzoate de denatonium
Ingredient · Denaturant · EWG: 1
Synthetic
Clean
See also: Denatonium (has active moiety).
Formula
C28H34N2O3
Mol. Weight
446.60
CAS #
3734-33-6
Form
Liquid
State
Solid; [Merck Index] White odorless solid; [EFSA: DAR - Vol. 1]
See origin →
Functions
Denaturant
Strengthens Barrier
Provides scent
Makes alcohol undrinkable
Traditional Use
A bitter-tasting synthetic compound developed in the 1950s as a denaturant. Added to cosmetics to discourage accidental ingestion, particularly in products like nail polish and hand sanitizers.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Allergen Warning
⚠️ EU Fragrance Allergen
EWG
1
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Denatonium Benzoate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Denatonium Benzoate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefi
Ligorio C, Tavasoli E, Karaman-Jurukovska N, Ittycheri A, Kotowska AM et al.
ACS applied bio materials, 2025
→
Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefi
Ligorio C, Tavasoli E, Karaman-Jurukovska N, Ittycheri A, Kotowska AM et al.
ACS applied bio materials, 2025
→
Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefi
Ligorio C, Tavasoli E, Karaman-Jurukovska N, Ittycheri A, Kotowska AM et al.
ACS applied bio materials, 2025
→
Management of acute radiation dermatitis: A review of the literature and proposal for treatment algorithm.
Rosenthal A, Israilevich R, Moy R
Journal of the American Academy of Dermatology, 2019
→
From Pine to Perfume.
Sagorin G, Cazeils E, Basset JF, Reiter M
Chimia, 2021
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR