Diethanolamine is used in a number of consumer products, such as shampoos, cosmetics, and pharmaceuticals. Limited information is available on the health effects of diethanolamine. Acute (short- term) inhalation exposure to diethanolamine in humans may result in irritation of the nose and throat, and dermal exposure may irritate the skin. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of diethanolamine in humans. Animal studies have reported effects on the liver, kidney, blood, and central nervous system (CNS) from chronic oral exposure to diethanolamine. The National Toxicology Program (NTP) reported an increased incidence of liver and kidney tumors in mice from dermal exposure to diethanolamine. EPA has not classified diethanolamine for carcinogenicity.
Solubility greater than or equal to 100 mg/mL at 57 °F (NTP, 1992)
Formula
C4H11NO2
Mol. Weight
105.14
CAS #
111-42-2
Form
Liquid
State
Diethanolamine appears as oily colorless liquid or solid white crystals. Slight rotten fish or ammonia odor. Denser than water. (USCG, 1999)
See origin →
Functions
Buffering
Quells irritation
Traditional Use
Organic compound synthesized in the early 20th century from ethylene oxide and ammonia. Adopted widely in cosmetics in the 1950s as a pH buffer and emulsifying agent, particularly in creams and shampoos.