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Diethyl Adipate
AKA “141-28-6, Diethyl hexanedioate, Ethyl adipate, 1, 6-Diethyl hexanedioate, Hexanedioic acid, diethyl ester, Adipic acid, 6-diethyl ester, diethyl-, Diethylester kyseliny adipove”
Emollient
Ingredient Facts
Diethyl adipate
AKA: 141-28-6, Diethyl hexanedioate, 1, 6-Diethyl hexanedioate, Hexanedioic acid, Diethyl ester, Adipic acid, 6-diethyl ester, Diethyl-, Diethylester kyseliny adipove
Emollient · Emollient · EWG: 4
Synthetic
Emollient
Skin Conditioner
Not Clean
Diethyl adipate is a fatty acid ester.
Solubility Soluble in ethanol and ethyl ether
Formula
C10H18O4
Mol. Weight
202.25
CAS #
141-28-6
Form
Liquid
State
Colorless liquid; [Hawley]
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
Traditional Use
Synthetic ester created in the early 20th century for use as a plasticizer and solvent in cosmetics. Designed to improve texture and spreadability of creams and lotions without traditional animal-derived alternatives.
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Final Report on the Safety Assessment of Adipic Acid Dihydrazide
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
1,4-Butanediol/Succinic Acid/Adipic Acid/HDI Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid/CHDM/MA/Neopentyl Glycol/Trimellitic Anhydride Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid/Neopentyl Glycol/Trimellitic Anhydride Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethyl Adipate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dimethyl Adipate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trimethylpentanediol/Adipic Acid/Glycerin Crosspolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Adipic Acid/Neopentyl Glycol/Trimellitic Anhydride Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Dimethyl Adipate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trimethylpentanediol/Adipic Acid/Glycerin Crosspolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Toxicity of adipic acid.
Kennedy GL Jr
Drug and chemical toxicology, 2002
→
Allergic Contact Dermatitis to Trimethylpentanediol/Adipic Acid/Glycerin Crosspolymer in a Lip Balm.
Lockmann A, Schill T, Schubert S, Buhl T
Contact dermatitis, 2026
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR