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Diethylene Glycol Diethylhexanoate/Diisononanoate
AKA “DIETHYLENE GLYCOL, 2'-Oxydiethanol, 2-(2-Hydroxyethoxy)ethanol, 2'-Oxybisethanol, Diglycol”
Synthetic
Ingredient Facts
Diethylene glycol diethylhexanoate/diisononanoate
AKA: 2'-Oxydiethanol, 2-(2-Hydroxyethoxy)ethanol, 2'-Oxybisethanol, Diglycol
Synthetic · Emollient · EWG: 4
Synthetic
Emollient
Skin Conditioner
Hair Care
Synthetic
Clean
Oxybis(2-hydroxyethyl), diesters with 3,5,5-trimethylhexanoic acid and 2-ethylhexanoic acid Science: Functions: Hair Conditioning, Plasticiser, Skin Conditioning, Skin Conditioning - Emollient Safety Ratings: CIR: Safe as used
Formula
C4H10O3
Mol. Weight
106.12
CAS #
111-46-6
Form
Liquid
See origin →
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Plasticiser
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
Traditional Use
Synthetic ester blend developed in the late 20th century as an emollient and carrier system for cosmetic ingredients. Designed to improve skin feel and product stability.
Skin Types
●all-skin-types
Best For
Dryness
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Insufficient
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
0.1%
0%0%
Reg. Limit
EU regulatory limit: 0.1%. Source: EU Cosmetics Regulation (EC) 1223/2009, Annex III (Restricted Substances), Entry 186.
Regulatory Status
USAunder review
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Enhanced skin permeation of a new capsaicin derivative (DA-5018) from a binary vehicle system composed of isopropyl myristate and ethoxydiglycol.
Cha BJ, Lee ED, Kim WB, Chung SJ, Lee MH et al.
Archives of pharmacal research, 2001
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Final Report on the Safety Assessment of Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
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Diethylene Glycol Diethylhexanoate/Diisononanoate
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Diethylene Glycol Diisononanoate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylene Glycol/DMAP Acrylamide/PEG-180/HDI Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ethoxydiglycol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Methoxydiglycol Methacrylate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylene Glycol Diethylhexanoate/Diisononanoate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ethoxydiglycol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethylene glycol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
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Methoxydiglycol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
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Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xer
Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A et al.
Journal of cosmetic dermatology, 2017
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Permeation Enhancer in Microemulsions and Microemulsion-Based Gels: A Comparison of Diethylene Glycol Monoethyl Ether and Oleyl Alcohol.
Pandey S, Baki G
Gels (Basel, Switzerland), 2025
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Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR