Diisopropanolamine
AKA “110-97-4, Bis(2-hydroxypropyl)amine, Bis(2-propanol)amine, 1, 1'-Iminodi-2-propanol, 2-Propanol, 1'-iminobis-, Di-2-propanolamine, di-isopropanolamine, DIPA (alcohol), Dipropyl-2, 2'-dihydroxy-amine
Ingredient
Ingredient Facts
Diisopropanolamine
AKA: 110-97-4, Bis(2-hydroxypropyl)amine, Bis(2-propanol)amine, 1, 1'-Iminodi-2-propanol, 2-Propanol, 1'-iminobis-, Di-2-propanolamine, Di-isopropanolamine, DIPA (alcohol), Dipropyl-2, 2'-dihydroxy-amine
Ingredient · Buffering · EWG: 5
Synthetic
Not Clean
Diisopropanolamine is a secondary amino compound that is diethanolamine substituted by methyl groups at positions 1 and 1'. It is a versatile chemical used in a variety of personal care, cosmetic and industrial products. It has a role as a surfactant, a buffer and an emulsifier. It is an aminodiol, a secondary alcohol and a secondary amino compound. It is functionally related to a 1-aminopropan-2-ol.
Solubility Soluble (>=10 mg/ml) (NTP, 1992)
Formula
C6H15NO2
Mol. Weight
133.19
CAS #
110-97-4
Form
Liquid
State
Diisopropanolamine appears as colorless liquid or white to yellow crystalline solid with an odor of dead fish or ammonia. Liquid floats and mixes with water. Solid sinks and mixes in water. (USCG, 199
See origin →
Functions
Buffering
Stabilizes pH
Traditional Use
Synthesized in the early 20th century as an organic chemical. Adopted by the cosmetics industry as a pH buffer and emulsifying agent to neutralize acids in formulations.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
5
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUpermitted
JAPANpermitted
CANADApermitted
Extended Re-review Summary: Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamines
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
2-Methyl-1-Phenyl-2-Propanol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Diisopropanolamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Pharmacokinetics and bioavailability of diisopropanolamine (DIPA) in rats following intravenous or dermal application.
Saghir SA, Frantz SW, Spence MW, Nolan RJ, Lowe ER et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR