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Dimethyl Adipate
AKA “Dimethyladipate, RefChem:134217, 627-93-0, Dimethyl hexanedioate, Adipic acid dimethyl ester, HEXANEDIOIC ACID, DIMETHYL ESTER, Adipic acid, dimethyl ester, 1, 6-Dimethylhexanedioate, MFCD00008469”
Emollient
Ingredient Facts
Dimethyl adipate
AKA: Dimethyladipate, RefChem:134217, 627-93-0, Dimethyl hexanedioate, Adipic acid dimethyl ester, HEXANEDIOIC ACID, DIMETHYL ESTER, Adipic acid, Dimethyl ester, 1, 6-Dimethylhexanedioate, MFCD00008469
Emollient · Emollient · EWG: 2
Synthetic
Emollient
Solvent
Skin Conditioner
Clean
Dimethyl adipate has been reported in Astragalus mongholicus and Astragalus membranaceus with data available.
Solubility Sol in alc, ether, acetic acid
Formula
C8H14O4
Mol. Weight
174.19
CAS #
627-93-0
Form
Liquid
State
Dimethyl adipate is a colorless liquid. (USCG, 1999)
See origin →
Functions
Plasticiser
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Locks In Moisture
Traditional Use
A synthetic ester developed as a cosmetic ingredient to serve as a humectant and solvent, providing hydration and improving the texture and spreadability of skincare and color cosmetic products.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
2
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
RIFM fragrance ingredient safety assessment, pentanedioic acid, 1,5-dimethyl ester, CAS Registry Number 1119-40-0.
Api AM, Belsito D, Botelho D, Browne D, Bruze M et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018
→
Final Report on the Safety Assessment of Adipic Acid Dihydrazide
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
1,4-Butanediol/Succinic Acid/Adipic Acid/HDI Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid/CHDM/MA/Neopentyl Glycol/Trimellitic Anhydride Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid/Neopentyl Glycol/Trimellitic Anhydride Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dimethyl Adipate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trimethylpentanediol/Adipic Acid/Glycerin Crosspolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Adipic Acid/Neopentyl Glycol/Trimellitic Anhydride Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Dimethyl Adipate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trimethylpentanediol/Adipic Acid/Glycerin Crosspolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Toxicity of adipic acid.
Kennedy GL Jr
Drug and chemical toxicology, 2002
→
Allergic Contact Dermatitis to Trimethylpentanediol/Adipic Acid/Glycerin Crosspolymer in a Lip Balm.
Lockmann A, Schill T, Schubert S, Buhl T
Contact dermatitis, 2026
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR