undefined 1
undefined 2
Dioctyl Adipate
AKA “123-79-5, Dioctyl hexanedioate, Di-n-octyl adipate, Hexanedioic acid, dioctyl ester, Dicaprylyl adipate, Adipic acid, 1, 6-dioctyl hexanedioate, 2BD76YG9SI, NSC-16201”
Ingredient
Ingredient Facts
Dioctyl adipate
AKA: 123-79-5, Dioctyl hexanedioate, Di-n-octyl adipate, Hexanedioic acid, Dioctyl ester, Dicaprylyl adipate, Adipic acid, 1, 6-dioctyl hexanedioate, 2BD76YG9SI, NSC-16201
Ingredient · Skin Conditioning · EWG: 4
Synthetic
Skin Conditioner
Not Clean
Dioctyl adipate has been reported in Streptomyces with data available.
Solubility INSOL IN WATER @ 25 °C; INSOL OR VERY SLIGHTLY SOL IN GLYCERINE & GLYCOLS; SOL IN MOST ORGANIC SOLVENTS
Formula
C22H42O4
Mol. Weight
370.60
CAS #
123-79-5
Form
Liquid
State
Liquid
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Traditional Use
A synthetic plasticizer and emollient developed in the 20th century. Used in cosmetics to improve product texture and skin feel; has no traditional history.
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Final Report on the Safety Assessment of Adipic Acid Dihydrazide
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Dioctyl Adipate and Diisopropyl Adipate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
1,4-Butanediol/Succinic Acid/Adipic Acid/HDI Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid/CHDM/MA/Neopentyl Glycol/Trimellitic Anhydride Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid/Neopentyl Glycol/Trimellitic Anhydride Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trimethylpentanediol/Adipic Acid/Glycerin Crosspolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Adipic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Adipic Acid/Neopentyl Glycol/Trimellitic Anhydride Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trimethylpentanediol/Adipic Acid/Glycerin Crosspolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Toxicity of adipic acid.
Kennedy GL Jr
Drug and chemical toxicology, 2002
→
Allergic Contact Dermatitis to Trimethylpentanediol/Adipic Acid/Glycerin Crosspolymer in a Lip Balm.
Lockmann A, Schill T, Schubert S, Buhl T
Contact dermatitis, 2026
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR