Disodium Glycyrrhizate
AKA “Disodium glycyrrhizin, UNII-L8Q0US0J7V, CCRIS 1966, Glycyrrhizinic acid disodium salt, DISODIUM GLYCYRRHIZATE [WHO-DD], alpha-D-Glucopyranosiduronic acid, (3-beta, disodium salt
Synthetic
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Ingredient Facts
Disodium glycyrrhizate
AKA: Disodium glycyrrhizin, UNII-L8Q0US0J7V, CCRIS 1966, Glycyrrhizinic acid disodium salt, DISODIUM GLYCYRRHIZATE [WHO-DD], Alpha-D-Glucopyranosiduronic acid, (3-beta, Disodium salt
Synthetic · Skin Conditioning | Soothing | Antioxidant · EWG: 4
Plant-Derived
Antioxidant
Soothing
Skin Conditioner
Synthetic
Clean
Derived from licorice root, this ingredient soothes and conditions skin, helping to calm irritation and improve overall skin comfort.
Formula
C42H59Na2O16-
Mol. Weight
865.90
CAS #
71277-79-7
Form
Powder
Plant-Derived
Synthetic. Derived from glycyrrhizin, the active compound isolated from licorice root (Glycyrrhiza glabra). Synthesized through neutralization of glycyrrhizin with sodium hydroxide to create the disodium salt form.
Function
Skin Conditioning | Soothing | Antioxidant
Benefits
Brightens uneven skin tone
Evens pigmentation
Quells irritation
Traditional Use
Derived from licorice root (used for over 4,000 years in Traditional Chinese Medicine and Ayurveda); the disodium salt form was developed to provide anti-inflammatory and skin-soothing benefits in modern cosmetics.
Skin Types
all-skin-types
Best For
Target
Redness
Melanin-Rich Skin
Suitable
Pregnancy Safe
Yes
EWG Score4
CIR Safety Findings
medical-approval, all-shades-safe, Not an Irritant
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR