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Dodecylhexadecyltrimonium Chloride
AKA “Tetrasal, Quartamin 280GP, UNII-75728NH7QU, (2-Dodecylhexadecyl)trimethylammonium chloride, N-(2-dodecyl)hexadecyl-N, N-trimethylammonium chloride, chloride, chloride (1:1)”
Synthetic
Ingredient Facts
Dodecylhexadecyltrimonium chloride
AKA: Tetrasal, Quartamin 280GP, UNII-75728NH7QU, (2-Dodecylhexadecyl)trimethylammonium chloride, N-(2-dodecyl)hexadecyl-N, N-trimethylammonium chloride, Chloride (1:1)
Synthetic · Cleansing · EWG: 4
Synthetic
Cleanser
Emulsifier
Skin Conditioner
Hair Care
Synthetic
Clean
A conditioning agent that helps reduce frizz and static while gently cleansing and blending ingredients together for a smooth, even texture.
Formula
C31H66ClN
Mol. Weight
488.30
CAS #
103807-18-7
Form
Liquid
See origin →
Functions
Antistatic
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Reduces Static
Conditions Hair
Cleansing Surfactant
Emulsifier
Lifts away dirt and oil
Reduces flyaways
Softens and detangles hair
Mixes oil and water
Traditional Use
A synthetic quaternary ammonium compound developed in the mid-20th century as a hair and skin conditioning agent. Created to replace natural conditioning substances and improve product texture and feel.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe w/Qualifications
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Benzalkonium Chloride.
, 2006
→
Benzalkonium Chloride.
, 2006
→
Substantivity of mouth-rinse formulations containing cetylpyridinium chloride and O-cymen-5-ol: a randomized-crossover trial.
Aguilera FR, Viñas M, Sierra JM, Vinuesa T, R Fernandez de Henestrosa A et al.
BMC oral health, 2022
→
Choline chloride-based deep eutectic solvent as an inhibitor of metalloproteases (collagenase and elastase) in cosmetic formulation.
Buarque FS, Monteiro E Silva SA, Ribeiro BD
3 Biotech, 2023
→
Final Report on the Safety Assessment of 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol Hydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2,4-Diaminophenol and 2,4-Diaminophenol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2,4-Diaminophenoxyethanol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Benzalkonium Chloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Benzethonium Chloride and Methylbenzethonium Chloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Cetrimonium Chloride, Cetrimonium Bromide, and Steartrimonium Chloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Chlorhexidine/Chlorhexidine Diacetate/Chlorhexidine Dihydrochloride/Chlorhexidine Digluconate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Methylene Chloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of N-Phenyl-p-Phenylenediamine, N-Phenyl-p-Phenylenediamine Hydrochloride, and N-Phenyl-p-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of PPG-9, -25, and -40 Diethylmonium Chloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Steapyrium Chloride and Lapyrium Chloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Stearalkonium Chloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Note Regarding the Safety Assessment of Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, and Chlorhexidine Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Polyaminopropyl Biguanide (polyhexamethylene biguanide hydrochloride) as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Acrylamide/Ethyltrimonium Chloride Acrylate/Ethalkonium Chloride Acrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Acrylamidopropyltrimonium Chloride/Acrylamide Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Acrylamidopropyltrimonium Chloride/Acrylates Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Behenalkonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Behentrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Benzalkonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Benzethonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Beta-Glucan Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Caesalpinia Spinosa Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cassia Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ceteartrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cetrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Chlorhexidine Dihydrochloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cocamidopropyl Betainamide MEA Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cocotrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cyclodextrin Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dextran Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dodecylhexadecyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Guar Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrogenated Palmtrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrogenated Tallowtrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxypropyl Guar Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Lapyrium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Lauralkonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Laurtrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Locust Bean Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Methylbenzethonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Octacosatrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Octyldodecyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PPG-25 Diethylmonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PPG-40 Diethylmonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PPG-9 Diethylmonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Soytrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Starch Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Steapyrium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Stearalkonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Stearoxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Steartrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Tallowtrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
TEA-Hydrochloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trigonella Foenum-Graecum Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Xanthan Hydroxypropyltrimonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Zinc Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Microstructural, Fluid Dynamic, and Mechanical Characterization of Zinc Oxide and Magnesium Chloride-Modified Hydrogel Scaffolds.
de Mello Innocentini MD, Fuzatto Bueno BR, Urbaś A, Morawska-Chochół A
ACS biomaterials science & engineering, 2024
→
Safety and efficacy of l-histidine monohydrochloride monohydrate produced using Corynebacterium glutamicum KCCM 80179 for all animal species.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, de Lourdes Bastos M, Christensen H et al.
EFSA journal. European Food Safety Authority, 2019
→
Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCC
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H et al.
EFSA journal. European Food Safety Authority, 2020
→
Acrylamidopropyltrimonium Chloride/Acrylamide Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Acrylamidopropyltrimonium Chloride/Acrylates Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Behenalkonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Behentrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Benzalkonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Benzethonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Bismuth Oxychloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cassia Hydroxypropyltrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ceteartrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cetrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Chlorhexidine Dihydrochloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Choline Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cocamidopropyl Betainamide MEA Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cocotrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Guar Hydroxypropyltrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxypropyl Guar Hydroxypropyltrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Lauralkonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Laurtrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Locust Bean Hydroxypropyltrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Magnesium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
PPG-9 Diethylmonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Sodium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Soytrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Starch Hydroxypropyltrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Steapyrium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Stearalkonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Steartrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Tallowtrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trigonella Foenum-Graecum Hydroxypropyltrimonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Zinc Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers.
Gwak HS, Oh IS, Chun IK
Drug development and industrial pharmacy, 2004
→
Aluminum chloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
b) As a conditioning agent in rinse-off hair care products, (i.e. benzalkonium chloride with chain lengths ≥ 16 C).
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
b) Not permitted in combination with aluminum chloride, aluminum chlorohydrate or its associated complexes or other aluminum zirconium complexes.
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Benzalkonium chloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Benzethonium chloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Benzyl chloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
c) Deodorants and antiperspirants containing aluminum chloride must be in the form of an aqueous solution.
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Carbon tetrachloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Chrysoidine citrate hydrochloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Diphenoxylate hydrochloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Methylene chloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Vinyl chloride monomer
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Safety Assessment of Polyaminopropyl Biguanide (Polyhexamethylene Biguanide Hydrochloride) as Used in Cosmetics.
Johnson W Jr, Boyer I, Zhu J, Bergfeld WF, Belsito DV et al.
International journal of toxicology, 2020
→
Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan.
Kawakami T, Isama K, Matsuoka A
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 2011
→
Structural properties of pepsin-solubilized collagen acylated by lauroyl chloride along with succinic anhydride.
Li C, Tian Z, Liu W, Li G
Materials science & engineering. C, Materials for biological applications, 2015
→
Methylbenzethonium chloride in the care of skin of infants and children.
LIPSCHUTZ A, FISCHER CC
A.M.A. American journal of diseases of children, 1955
→
Impact of Dietary Zinc Chloride Hydroxide and Zinc Methionine on the Faecal Microbiota of Healthy Adult Horses and Ponies.
Paßlack N, van Bömmel-Wegmann S, Vahjen W, Zentek J
Journal of equine veterinary science, 2022
→
Combined effect of silver nanoparticles and aluminium chloride, butylparaben or diethylphthalate on the malignancy of MDA-MB-231 breast cancer cells a
Roszak J, Smok-Pieniążek A, Jeżak K, Domeradzka-Gajda K, Grobelny J et al.
Toxicology in vitro : an international journal published in association with BIBRA, 2020
→
Chlorhexidine Dihydrochloride Shows Anti-tumor Effects in Desmoid Tumors and Colorectal Cancer.
Shin H, Kim Y, Lee Y, Kim J, Ryu YC et al.
Anticancer research, 2024
→
Trisodium Phosphate and Cetylpyridinium Chloride Spraying on Chicken Skin to Reduce Attached Salmonella typhimurium.
Wang WC, Li Y, Slavik MF, Xiong H
Journal of food protection, 1997
→
Chitosan-Glycolic Acid Gel Modification of Chloride Ion T...
Olga Zavyalova, Dominika Dąbrowska-Wisłocka, Konrad Misiura, Iga Hołyńska-Iwan
Molecules (Basel, Switzerland), 2023
→
Chitosan-Glycolic Acid Gel Modification of Chloride Ion T...
Olga Zavyalova, Dominika Dąbrowska-Wisłocka, Konrad Misiura, Iga Hołyńska-Iwan
Molecules (Basel, Switzerland), 2023
→
Chitosan-Glycolic Acid Gel Modification of Chloride Ion T...
Olga Zavyalova, Dominika Dąbrowska-Wisłocka, Konrad Misiura, Iga Hołyńska-Iwan
Molecules (Basel, Switzerland), 2023
→
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR