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EDTA
AKA “Edetic acid, Ethylenediaminetetraacetic acid, Edathamil, Sequestrol, Havidote, Titriplex, EDTA acid, Sequestrene aa”
Synthetic
Ingredient Facts
EDTA
AKA: Edetic acid, Ethylenediaminetetraacetic acid, Edathamil, Sequestrol, Havidote, Titriplex, EDTA acid, Sequestrene aa
Synthetic · Antimicrobial · EWG: 4
Synthetic
Preservative
Chelating Agent
Synthetic
Clean
Helps keep formulas stable and effective by preventing minerals from interfering with the product's performance and texture.
Solubility 1000000
Formula
C10H16N2O8
Mol. Weight
292.24
CAS #
60-00-4
Form
Powder
State
Ethylenediamine tetraacetic acid is a colorless crystalline solid. It is slightly soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its sp
See origin →
Functions
Chelating
Grabs onto metal ions in water that would destabilize the formula. Keeps your product from going bad or changing color.
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Removes Metal Ions
Binds metal ions
Traditional Use
Developed as a synthetic chelating agent in the 1930s by German chemists. Widely adopted in cosmetics from the 1950s onward to bind metal ions, prevent oxidation, and improve product stability.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe w/Qualifications
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
EDTA and Salts
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, HEDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, and Trisod
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Calcium Disodium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diammonium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dipotassium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
HEDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
TEA-EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Tetrasodium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Tripotassium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium HEDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Calcium Disodium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Dipotassium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Disodium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Tetrasodium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Tripotassium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium HEDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
→
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR