Elastin
AKA “Elastins, (2S)-1-[(2S)-2-[[2-[[(2S, (2S)-1-((2S)-2-((2-(((2S, 3S)-2-(((2S)-2-acetamido-4-methyl-pentanoyl)amino)-3-methyl-pentanoyl)amino)acetyl)amino)-3-methyl-butanoyl)-N-methyl-pyrrolidine-2-carboxamide, RefChem:136452, UNII-VRC4754D50, EINECS 232-701-4”
Synthetic
Ingredient Facts
Elastin
AKA: Elastins, (2S)-1-[(2S)-2-[[2-[[(2S, (2S)-1-((2S)-2-((2-(((2S, 3S)-2-(((2S)-2-acetamido-4-methyl-pentanoyl)amino)-3-methyl-pentanoyl)amino)acetyl)amino)-3-methyl-butanoyl)-N-methyl-pyrrolidine-2-carboxamide, RefChem:136452, UNII-VRC4754D50, EINECS 232-701-4
Synthetic · Smoothing · EWG: 4
Synthetic
Skin Conditioner
Synthetic
Clean
Elastin helps skin stay firm and supple by improving elasticity and smoothness. This protein works to reduce the appearance of fine lines and wrinkles.
Effective at 8.25%
Formula
C27H48N6O6
Mol. Weight
552.70
CAS #
9007-58-3
Form
Powder
State
Powder; [Sigma-Aldrich MSDS]
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Smoothing
Improves skin elasticity
Locks in moisture
Smooths skin texture
Traditional Use
A structural protein extracted from animal tissues; first isolated scientifically in the 19th century. Used in modern skincare based on the belief it can improve skin elasticity, though topical application has limited efficacy as the protein molecule is too large to penetrate skin.
Skin Types
●all-skin-types
Best For
Loss of Elasticity
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
4e-06%
16.5%
0%100%
Effective Range
CIR reported use: 0.000004-6 | 0.00003-16.5
Regulatory Agencies
Elastin
European Commission
EU Cosmetic Ingredient Database (CosIng)
Elastin Amino Acids
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hydrolyzed Elastin
European Commission
EU Cosmetic Ingredient Database (CosIng)
Soluble Elastin
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hydrolyzed Elastin
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Soluble Elastin
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Investigation of water-soluble elastin as a multifunctional cosmetic material: Moisturizing and whitening effects.
Inoue A, Hikima T, Taniguchi S, Nose T, Maeda I
Journal of cosmetic science, 2017
Does human leukocyte elastase degrade intact skin elastin?
Schmelzer CE, Jung MC, Wohlrab J, Neubert RH, Heinz A
The FEBS journal, 2012
Elastin is heterogeneously cross-linked.
Schräder CU, Heinz A, Majovsky P, Karaman Mayack B, Brinckmann J et al.
The Journal of biological chemistry, 2018
Elastin is heterogeneously cross-linked.
Schräder CU, Heinz A, Majovsky P, Karaman Mayack B, Brinckmann J et al.
The Journal of biological chemistry, 2018
Elastin is heterogeneously cross-linked.
Schräder CU, Heinz A, Majovsky P, Karaman Mayack B, Brinckmann J et al.
The Journal of biological chemistry, 2018
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR