Gluconolactone
AKA “90-80-2, delta-gluconolactone, D-glucono-1, 5-lactone, Gluconic acid lactone, (3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one, D-Gluconic acid lactone, D-Gluconic acid delta-lactone, 1, 5-D-Gluconolactone, Gluconic lactone”
Synthetic
Ingredient Facts
Gluconolactone
AKA: 90-80-2, Delta-gluconolactone, D-glucono-1, 5-lactone, Gluconic acid lactone, (3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one, D-Gluconic acid lactone, D-Gluconic acid delta-lactone, 1, 5-D-Gluconolactone, Gluconic lactone
Synthetic · Skin Conditioning · EWG: 1
Synthetic
Skin Conditioner
Chemical Exfoliant
Synthetic
Clean
Gluconolactone is a naturally occurring polyhydroxy acid (PHA) with metal chelating, moisturizing and antioxidant activity. Gluconolactone can be produced by enzymatic oxidation of D-glucose oxidation. Its ability in free radicals scavenging accounts for its antioxidant property. It is used in cosmetic product and as a coagulant in tofu processing. (NCI05)
Solubility 590000
Formula
C6H10O6
Mol. Weight
178.14
CAS #
90-80-2
State
Dry Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Removes Metal Ions
Conditions Skin
Binds metal ions
Traditional Use
This is not an ingredient name—it appears to be a purity specification or percentage notation.
Skin Types
●all-skin-types
Best For
General
KP smoothing stick
Cocokind
smooth + hydrate body stick duo
Cocokind
retinol face + body duo
Cocokind
Sunless Tan Anti-Aging Daily Face Moisturizer
COOLA
Refreshing Water Cream
COOLA
Day SPF 30 & Night Eye Cream
COOLA
Face Sunscreen Lotion - Fragrance Free
COOLA
Glowing Greens Detoxifying Facial Cleansing Gel
COOLA
Hydrating Sunscreen Lotion - Peach Blossom
COOLA
3 Piece Classic Suncare Travel Set
COOLA
Suncare Travel Essentials Set
COOLA
Anti-aging Dream Duo • SPF 50 + Retinol
Odacité
Blemish Control System
Odacité
Retinol Therapy • Renewing Hand Cream • PHA + Peptides
Odacité
Sun Damage Defense Duo • SPF 50 + Vitamin C
Odacité
Anti Aging Eye & Sun Defense Duo
Odacité
Fall Reset Box
Odacité
Detox Hydrating Gel
Goldfaden MD
AM + PM Hydrating Booster Set
Goldfaden MD
Detox & Clarify Collection
Goldfaden MD
Phaze™ Gel Cleanser
Pai Skincare
Phaze™ Gel Cleanser Mini
Pai Skincare
Retinol Alternative Cream
Indie Lee
Tulip Dew Drops
Bloom Effects
Black Tulip Eye Treatment
Bloom Effects
Black Tulip Facial Treatment
Bloom Effects
Radiance Reset
Bloom Effects
Everyday Radiance Essentials
Bloom Effects
Balance + Support Duo
Marie Veronique
Hoppin’ Fresh Deodorant
Ursa Major
Mountain Glow Serum
Ursa Major
The New Tendency Duo
Nécessaire
The New Tendency Complete Set
Nécessaire
The Body Wash Discovery Collection
Nécessaire
The Body Duo
Nécessaire
The Body Brush
Nécessaire
Fantastic Face Wash Two-Pack
Ursa Major
Soothing B3 Serum
Marie Veronique
Intensive Repair Serum
Marie Veronique
Fantastic Face Wash Traveler
Ursa Major
Fantastic Face Wash
Ursa Major
Supernutrient Firming Facial
Marie Veronique
COLORFREE ZINC Broad Spectrum Sunscreen | SPF 32
Marie Veronique
Body Barrier Emulsion
Marie Veronique
Barrier Restore Serum
Marie Veronique
All Day Age-Delay Emulsion
Marie Veronique
Advanced Repair Eye Cream
OSEA
Soothing Cleanser
Indie Lee
Sensitive Skin Regimen
Indie Lee
Bye-Bye Redness Regimen
Indie Lee
Gluconolactone
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Gluconolactone restores immune regulation and alleviates skin inflammation in lupus-prone mice and in patients with cutaneous lupus.
Li W, Kolios AGA, Pan W, Burbano C, Karino K et al.
Science translational medicine, 2025
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR