Glucosamine Sulfate
AKA “Glucosamine sulphate, Tiocondramina, 1FW7WLR731, Faximin, Dona, Glucosamine Sulfate Salt, D-Glucose, 2-amino-2-deoxy-, sulfate (salt), Dolenio, Glusartel”
Skin Conditioning
Ingredient Facts
Glucosamine sulfate
AKA: Glucosamine sulphate, Tiocondramina, 1FW7WLR731, Faximin, Dona, Glucosamine Sulfate Salt, D-Glucose, 2-amino-2-deoxy-, Sulfate (salt), Dolenio, Glusartel
Skin Conditioning · Skin Conditioning · EWG: 1
Synthetic
Skin Conditioner
Clean
Glucosamine Sulfate is an amino sugar (2-amino, 2-deoxyglucose) in cell membranes, Glucosamine Sulfate is believed to play a role in cartilage formation and repair. Long-term glucosamine sulfate treatment retards progression of knee osteoarthritis; the mechanism appears to involve glucosamine's role as an essential substrate for glycosaminoglycans and hyaluronic acid, needed for formation of the joint proteoglycan structural matrix. (NCI04)
Formula
C12H28N2O14S
Mol. Weight
456.42
CAS #
29031-19-4
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
A sulfate salt form of glucosamine developed for improved bioavailability; traditionally glucosamine was sourced from marine organisms and used in folk medicine, with modern sulfate formulation optimizing its cosmetic efficacy.
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Caution
EWG
1
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
medical-approval
all-shades-safe
Dermal Absorption 5%
Concentration Guide
Dermal absorption: 5%. Source: CIR Safety Assessment (CIR Seq 832).
Regulatory Agencies
Transdermal co-delivery of glucosamine sulfate and diacerein for the induction of chondroprotection in experimental osteoarthritis.
Chattopadhyay H, Auddy B, Sur T, Gupta M, Datta S
Drug delivery and translational research, 2020
Final Report of the Amended Safety Assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glycer
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behen
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Glucosamine Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Glyceryl Arachidonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Dietary olive oil intake aggravates psoriatic skin inflammation in mice via Nrf2 activation and polyunsaturated fatty acid imbalance.
Donato-Trancoso A, Correa Atella G, Romana-Souza B
International immunopharmacology, 2022
Glucosamine Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Glyceryl Arachidonate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Bioavailability of potassium from potatoes and potassium gluconate: a randomized dose response trial.
Macdonald-Clarke CJ, Martin BR, McCabe LD, McCabe GP, Lachcik PJ et al.
The American journal of clinical nutrition, 2016
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR