undefined 1
undefined 2
undefined 3
undefined 4
undefined 5
undefined 6
Glyceryl Thioglycolate
AKA “Glyceryl monothioglycolate, 30618-84-9, Glycerol monomercaptoacetate, Acetic acid, 2-mercapto-, monoester with 1, 2, 3-propanetriol, CHEBI:156545, 0FWE72AF2P, Mercaptoacetic acid, RefChem:663554, DTXSID2027965, 250-264-8”
Ingredient
Ingredient Facts
Glyceryl thioglycolate
AKA: Glyceryl monothioglycolate, 30618-84-9, Glycerol monomercaptoacetate, Acetic acid, 2-mercapto-, Monoester with 1, 2, 3-propanetriol, CHEBI:156545, 0FWE72AF2P, Mercaptoacetic acid, RefChem:663554, DTXSID2027965, 250-264-8
Ingredient · Hair Waving Or Straightening · EWG: 5
Synthetic
Not Clean
Mercaptoacetic acid, monoester with propane-1,2,3-triol
Formula
C5H10O4S
Mol. Weight
166.20
CAS #
30618-84-9
Form
Liquid
State
Colorless viscous liquid with a mild sulfurous odor; [Lanza Research MSDS]
See origin →
Functions
Hair Waving Or Straightening
Moisturizing
Strengthens Barrier
Changes hair texture
Traditional Use
A synthetic derivative combining glycerin with thioglycolic acid, developed in the mid-20th century. Created specifically for use in permanent wave (perm) hair treatments and hair straightening formulations.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
5
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics.
Burnett CL, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics.
Burnett CL, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
Sodium Dehydroacetate and Dehydroacetic Acid.
Cherian P, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2024
→
Sodium Dehydroacetate and Dehydroacetic Acid.
Cherian P, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2024
→
Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl T
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Ammonium and Glyceryl Thioglycolates and Thioglycolic Acid
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Sodium Dehydroacetate and Dehydroacetic Acid
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Sodium Dehydroacetate and Dehydroacetic Acid
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Acetic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Beta-Alanine Diacetic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
dehydroacetic acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glyceryl Thioglycolate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Acetic acid and the skin: a review of vinegar in dermatology.
Elhage KG, St Claire K, Daveluy S
International journal of dermatology, 2022
→
Acetic acid and the skin: a review of vinegar in dermatology.
Elhage KG, St Claire K, Daveluy S
International journal of dermatology, 2022
→
Acetic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
dehydroacetic acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glyceryl Thioglycolate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Potential application of novel liquid crystal nanoparticles of isostearyl glyceryl ether for transdermal delivery of 4-biphenyl acetic acid.
Fujii MY, Asakawa Y, Fukami T
International journal of pharmaceutics, 2020
→
Preparation of (13)C-labeled ceramide by acetic acid bacteria and its incorporation in mice.
Fukami H, Tachimoto H, Kishi M, Kaga T, Waki H et al.
Journal of lipid research, 2010
→
Trichloroacetic acid
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
[Pharmacological studies of N-(2-mercapto-2-methylpropionyl)-L-cysteine (SA 96). VI. Effects on vitamin B6, metals and skin collagen in rats].
Yamauchi H, Morikawa K, Kuwano M, Hikida M, Fujimura K et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1985
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR