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Glycyrrhetinic Acid
AKA “enoxolone, Glycyrrhetic acid, Uralenic acid, 471-53-4, 18-beta-Glycyrrhetinic acid, Enoxolona, 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid, Enoxolonum, Rhetinic Acid”
Acid
Ingredient Facts
Glycyrrhetinic acid
AKA: Enoxolone, Glycyrrhetic acid, Uralenic acid, 471-53-4, 18-beta-Glycyrrhetinic acid, Enoxolona, 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid, Enoxolonum
Acid · Skin Conditioning · EWG: 3
Synthetic
Skin Conditioner
Acid
Not Clean
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta., 20.beta.)-
Formula
C30H46O4
Mol. Weight
470.70
CAS #
471-53-4
Form
Liquid
State
Solid
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
The active triterpene compound extracted from licorice root, isolated and studied extensively in the 1970s-1980s. Used in skincare for anti-inflammatory and skin-soothing properties, building on licorice's traditional use in Asian medicine.
Skin Types
●all-skin-types
Best For
Redness
Pregnancy & Breastfeeding Safe
Caution
EWG
3
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not an Irritant
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Final Report on the Safety Assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammon
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Allantoin Glycyrrhetinic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycyrrhetinic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
→
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
→
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
→
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
→
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
→
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
→
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
→
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
→
Allantoin Glycyrrhetinic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycyrrhetinic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR