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hexadecyl D-glucoside
AKA “54549-27-8, Hexadecyl D-glucopyranoside, RefChem:347484, cetyl glucoside, (3R, 4S, 5S, 6R)-2-hexadecoxy-6-(hydroxymethyl)oxane-3, 4, 5-triol, EINECS 259-220-2, SCHEMBL322938, PAEMERHSTIDLSE-VEIQOZLZSA-N, DTXSID001009980”
Ingredient
Ingredient Facts
Hexadecyl d-glucoside
AKA: 54549-27-8, Hexadecyl D-glucopyranoside, RefChem:347484, Cetyl glucoside, (3R, 4S, 5S, 6R)-2-hexadecoxy-6-(hydroxymethyl)oxane-3, 4, 5-triol, EINECS 259-220-2, SCHEMBL322938, PAEMERHSTIDLSE-VEIQOZLZSA-N, DTXSID001009980
Ingredient · Cleansing · EWG: 4
Synthetic
Cleanser
Not Clean
hexadecyl D-glucoside is a cosmetic ingredient. Also known as 54549-27-8. Assessed as safe by the CIR.
Formula
C22H44O6
Mol. Weight
404.60
CAS #
54549-27-8
Form
Liquid
See origin →
Functions
Surfactant
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Traditional Use
A modern biodegradable surfactant developed from glucose and fatty alcohols in the late 20th century. It was designed as a gentler alternative to synthetic surfactants while maintaining cleansing efficacy.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR