Hexamidine
AKA “3811-75-4, Hexamidina, Hexamidinum, 4, 4'-(1, 6-Hexanediylbis(oxy))bis-benzenecarboximidamide, 3483C2H13H, CHEBI:87184, DTXSID60191524, Benzenecarboximidamide, 6-hexanediylbis(oxy))bis-, 1, 6-di(para-amidinophenoxy)hexane”
Preservative
Ingredient Facts
Hexamidine
AKA: 3811-75-4, Hexamidina, Hexamidinum, 4, 4'-(1, 6-Hexanediylbis(oxy))bis-benzenecarboximidamide, 3483C2H13H, CHEBI:87184, DTXSID60191524, Benzenecarboximidamide, 6-hexanediylbis(oxy))bis-, 1, 6-di(para-amidinophenoxy)hexane
Preservative · Preservative · EWG: 4
Synthetic
Preservative
Not Clean
Benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-
Formula
C20H26N4O2
Mol. Weight
354.40
CAS #
3811-75-4
Form
Powder
See origin →
Functions
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Preserves Formula
Fights Bacteria
Reduces Inflammation
Wound Healing
Prevents microbial growth
Traditional Use
Developed in the mid-20th century as a synthetic antimicrobial agent. It was created specifically for use in cosmetics and personal care products as a preservative and antibacterial component.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
0.1%
0%0%
Reg. Limit
EU regulatory limit: 0.1%. Source: EU Cosmetics Regulation (EC) 1223/2009, Annex V (Preservatives), Entry 47.
Regulatory Agencies
Hexamidine and Hexamidine Diisethionate.
Cherian P, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2023
Final Report on the Safety Assessment of Hexamidine and Hexamidine Diisethionate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Hexamidine and Hexamidine Diisethionate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Hexamidine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hexamidine Diisethionate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hexamidine Diisethionate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Hexamidine salts - applications in skin health and personal care products.
Parisi N, Matts PJ, Lever R, Hadgraft J, Lane ME
International journal of cosmetic science, 2017
Topical delivery of hexamidine.
Parisi N, Paz-Alvarez M, Matts PJ, Lever R, Hadgraft J et al.
International journal of pharmaceutics, 2016
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR