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Hexamidine Diisethionate
AKA “659-40-5, Hexamidine isethionate, hexomedin, hexamidine isetionate, 023XA5Z50L, NSC-115848, RF-2535, DTXSID60984372, Laryngomedin N”
Preservative
Ingredient Facts
Hexamidine diisethionate
AKA: 659-40-5, Hexamidine isethionate, Hexomedin, Hexamidine isetionate, 023XA5Z50L, NSC-115848, RF-2535, DTXSID60984372, Laryngomedin N
Preservative · Antimicrobial · EWG: 1
Synthetic
Preservative
Clean
2-Hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1)
Formula
C24H38N4O10S2
Mol. Weight
606.70
CAS #
659-40-5
Form
Powder
See origin →
Functions
Anti-Seborrheic
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Controls excess oil
Fights acne
Causing bacteria
Traditional Use
A salt form of hexamidine developed in the mid-20th century for improved solubility and stability in cosmetic formulations. It was designed as an antimicrobial preservative to protect products from bacterial and fungal contamination.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
1
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
0.1%
0%0%
Reg. Limit
EU regulatory limit: 0.1%. Source: EU Cosmetics Regulation (EC) 1223/2009, Annex V (Preservatives), Entry 47.
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR