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Hexanediol
AKA “1, 6-HEXANEDIOL, Hexane-1, 6-diol, 629-11-8, Hexamethylene glycol, 6-Dihydroxyhexane, Hexamethylenediol, alpha, omega-Hexanediol, DTXSID1027265, ZIA319275I, DTXCID907265”
Ingredient
Ingredient Facts
Hexanediol
AKA: 1, 6-HEXANEDIOL, Hexane-1, 6-diol, 629-11-8, Hexamethylene glycol, 6-Dihydroxyhexane, Hexamethylenediol, Alpha, Omega-Hexanediol, DTXSID1027265, ZIA319275I, DTXCID907265
Ingredient · Solvent · EWG: 1
Synthetic
Solvent
Clean
Hexane-1,6-diol is a diol that is hexane substituted by hydroxy groups at positions 1 and 6. It is a primary alcohol and a diol. It derives from a hydride of a hexane.
Solubility Soluble in water
Formula
C6H14O2
Mol. Weight
118.17
CAS #
629-11-8
Form
Liquid
State
Liquid, Other Solid; Other Solid
See origin →
Functions
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Dissolves Ingredients
Antioxidant Protection
Locks In Moisture
Fights Bacteria
Dissolves other ingredients
Traditional Use
Developed in the mid-20th century as a synthetic humectant and preservative booster. It was created to improve hydration in skincare products while providing antimicrobial support in cosmetic formulations.
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Moderate Irritant
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
2-Ethyl-1,3-hexanediol.
Ballantyne B
Journal of applied toxicology : JAT, 2005
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Fragrance material review on alpha-amylcinnamyl alcohol.
Bhatia SP, Wellington GA, Cocchiara J, Lalko J, Letizia CS et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007
→
Fragrance material review on dihydro-alpha-terpineol.
Bhatia SP, McGinty D, Letizia CS, Api AM
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008
→
Final Report on the Safety Assessment of Ethyl Hexanediol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Sodium Alpha-Olefin Sulfonates
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of alpha-Amino Acids as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Sodium alpha-Olefin Sulfonates
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Alpha-Isomethyl Ionone
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ethyl Hexanediol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hexanediol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hexanediol Distearate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Thioctic (Alpha Lipoic) Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
1,2-Hexanediol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2-HEXANEDIOL
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Alpha-Isomethyl Ionone
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cholecalciferol, 1 Alpha,25 Dihydroxy
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ethyl Hexanediol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hexanediol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Synergistic/antagonistic antimicrobial effects of cosmetic ingredients in combination with 1,2-hexanediol.
Gim H, Hong S, Park H, Im S, Kim JI
Journal of microorganism control, 2024
→
Synergistic/antagonistic antimicrobial effects of cosmetic ingredients in combination with 1,2-hexanediol.
Gim H, Hong S, Park H, Im S, Kim JI
Journal of microorganism control, 2024
→
Alpha-hydroxy acids, including polyhydroxy acids and bionic acids with alpha hydroxyl groups, and their salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
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[Percutaneous absorption of drug from alpha-olefin oligomer gel bases].
Kaiho F, Hirose C, Shimizu A, Sunada K, Isoyama A et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1992
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Effects of antioxidant polyphenols on TNF-alpha-related diseases.
Kawaguchi K, Matsumoto T, Kumazawa Y
Current topics in medicinal chemistry, 2011
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Effects of antioxidant polyphenols on TNF-alpha-related diseases.
Kawaguchi K, Matsumoto T, Kumazawa Y
Current topics in medicinal chemistry, 2011
→
Effects of antioxidant polyphenols on TNF-alpha-related diseases.
Kawaguchi K, Matsumoto T, Kumazawa Y
Current topics in medicinal chemistry, 2011
→
Effects of 1 alpha,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsor
Limat A, Hunziker T, Braathen LR
Archives of dermatological research, 1993
→
Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.
Liu H, Yu H, Xia J, Liu L, Liu GJ et al.
The Cochrane database of systematic reviews, 2020
→
Uptake and bioconversion of alpha-tocopheryl acetate to a...
E P Norkus, G F Bryce, H N Bhagavan
Photochemistry and photobiology, 1993
→
Uptake and bioconversion of alpha-tocopheryl acetate to a...
E P Norkus, G F Bryce, H N Bhagavan
Photochemistry and photobiology, 1993
→
Uptake and bioconversion of alpha-tocopheryl acetate to a...
E P Norkus, G F Bryce, H N Bhagavan
Photochemistry and photobiology, 1993
→
Safety of alpha-arbutin and beta-arbutin in cosmetic products
Scientific Committee on Consumer Safety (SCCS)
European Commission — SCCS
→
Evaluation of the Synthesis and Skin Penetration Pathway of Folate-Conjugated Polymeric Micelles for the Dermal Delivery of Irinotecan and Alpha-Mango
Sirirak T, Subongkot T
Pharmaceutics, 2025
→
Assessment of the potential risk of 1,2-hexanediol using phytotoxicity and cytotoxicity testing.
Song U, Kim J
Ecotoxicology and environmental safety, 2020
→
The Efficacy of Topical Cosmetic Containing Alpha-Arbutin...
Pimpa Tantanasrigul, Apinya Sripha, Bunchai Chongmelaxme
Journal of cosmetic dermatology, 2025
→
The Efficacy of Topical Cosmetic Containing Alpha-Arbutin...
Pimpa Tantanasrigul, Apinya Sripha, Bunchai Chongmelaxme
Journal of cosmetic dermatology, 2025
→
The Efficacy of Topical Cosmetic Containing Alpha-Arbutin...
Pimpa Tantanasrigul, Apinya Sripha, Bunchai Chongmelaxme
Journal of cosmetic dermatology, 2025
→
Improvement of Skin Condition Through RXR Alpha-Activating Materials.
Ye S, Lee S, Kang S, Jun SH, Kang NG
Biomolecules, 2025
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR