Hexapeptide-12
AKA “RefChem:787430, Ala-pro-gly-val-gly-val, L-Valine, UNII-M5Z12Z67BG, Hexapeptide-12 (ala-pro-gly-val-gly-val), Hexapeptide-12 (ala-pro-gly-val-gly-val) [INCI]”
Synthetic
Ingredient Facts
Hexapeptide-12
AKA: RefChem:787430, Ala-pro-gly-val-gly-val, L-Valine, UNII-M5Z12Z67BG, Hexapeptide-12 (ala-pro-gly-val-gly-val), Hexapeptide-12 (ala-pro-gly-val-gly-val) [INCI]
Synthetic · Soothing · EWG: 4
Synthetic
Soothing
Skin Conditioner
Synthetic
Clean
A gentle peptide that helps skin feel soft and smooth by improving moisture retention and overall skin conditioning.
Formula
C22H38N6O7
Mol. Weight
498.60
CAS #
-
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Soothing
Calms redness, irritation, and inflammation. Your skin's chill pill — great for sensitive, reactive, or post-procedure skin.
Boosts collagen production
Reduces fine lines
Traditional Use
A synthetic peptide developed in modern cosmetic research to mimic natural skin signaling molecules. Created to reduce facial muscle contractions and improve skin firmness without invasive procedures.
Skin Types
●all-skin-types
Best For
Wrinkles
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
Safety Assessment of Tripeptide-1, Hexapeptide-12 Their Metal Salts and Fatty Acid Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Hexapeptide-12
European Commission
EU Cosmetic Ingredient Database (CosIng)
Myristoyl Hexapeptide-12
European Commission
EU Cosmetic Ingredient Database (CosIng)
Palmitoyl Hexapeptide-12
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hexapeptide-12
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Palmitoyl Hexapeptide-12
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefi
Ligorio C, Tavasoli E, Karaman-Jurukovska N, Ittycheri A, Kotowska AM et al.
ACS applied bio materials, 2025
Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefi
Ligorio C, Tavasoli E, Karaman-Jurukovska N, Ittycheri A, Kotowska AM et al.
ACS applied bio materials, 2025
Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefi
Ligorio C, Tavasoli E, Karaman-Jurukovska N, Ittycheri A, Kotowska AM et al.
ACS applied bio materials, 2025
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR