Hexapeptide-9
AKA “Collaxyl, Argireline Also Known As: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2”
Peptide
Ingredient Facts
Hexapeptide-9
AKA: Collaxyl, Argireline Also Known As: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Peptide · Anti-Aging
Synthetic
Anti-Aging
Skin Conditioner
Amino Acid
Peptide
Clean
Formula
C24H38N8O9
Mol. Weight
582.6
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Anti-Aging
Targets fine lines, wrinkles, or loss of firmness. Works by boosting collagen, speeding cell turnover, or both.
Boosts collagen production
Reduces fine lines
Traditional Use
A synthetic peptide developed in the early 2000s designed to mimic natural skin proteins and support skin firmness. Created to address age-related collagen loss through targeted molecular signaling.
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Yes
Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
Chang H, Tao K, Yang Y, Wang Y, Ge M et al.
Journal of cosmetic dermatology, 2025
Hexapeptide-9
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hexapeptide-9
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Verified Feb 2026
Data: PubChem · CosIng · CIR