Hexapeptide-9
AKA “885024-94-2, Apepbiosix-5, Glycyl-L-prolyl-L-glutaminylglycyl-L-prolyl-L-glutamine, Hexapeptide-9 [INCI], Gly-Pro-Gln-Gly-Pro-Gln, L25414IE41, UNII-L25414IE41, L-Glutamine, glycyl-L-prolyl-L-glutaminylglycyl-L-prolyl-, RefChem:201160
Skin Conditioning
Ingredient Facts
Hexapeptide-9
AKA: 885024-94-2, Apepbiosix-5, Glycyl-L-prolyl-L-glutaminylglycyl-L-prolyl-L-glutamine, Hexapeptide-9 [INCI], Gly-Pro-Gln-Gly-Pro-Gln, L25414IE41, UNII-L25414IE41, L-Glutamine, Glycyl-L-prolyl-L-glutaminylglycyl-L-prolyl-, RefChem:201160
Skin Conditioning · Skin Conditioning · EWG: 1
Synthetic
Skin Conditioner
Amino Acid
Clean
Hexapeptide-9 is a synthetic peptide containing Glutamine, Glycine and Proline residues
Formula
C24H38N8O9
Mol. Weight
582.60
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Boosts collagen production
Reduces fine lines
Traditional Use
A synthetic peptide developed in the early 2000s designed to mimic natural skin proteins and support skin firmness. Created to address age-related collagen loss through targeted molecular signaling.
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Insufficient
Pregnancy
Yes
Regulatory Status
USAunder review
EUrestricted
JAPANrestricted
CANADArestricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR