Histidine HCl
AKA “L-Histidine hydrochloride, 645-35-2, 1007-42-7, Histidine hydrochloride, Histidine monohydrochloride, L-Histidine, monohydrochloride, L-Histidine monohydrochloride, L-Histidine hydrochloride (VAN), L-”
Skin Conditioning
Ingredient Facts
Histidine hcl
AKA: L-Histidine hydrochloride, 645-35-2, 1007-42-7, Histidine hydrochloride, Histidine monohydrochloride, L-Histidine, Monohydrochloride, L-Histidine monohydrochloride, L-Histidine hydrochloride (VAN), L-
Skin Conditioning · Hair Conditioning · EWG: 1
Synthetic
Skin Conditioner
Hair Care
Clean
Histidine HCl is a cosmetic ingredient used as hair conditioning, skin conditioning. Also known as L-Histidine hydrochloride. Rated low hazard by EWG. Assessed as safe by the CIR.
Formula
C6H10ClN3O2
Mol. Weight
191.61
CAS #
645-35-2, 5934-29-2
Form
Powder
State
Fine white crystals; [Sigma-Aldrich MSDS]
See origin →
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
The hydrochloride salt form of the amino acid histidine, developed for cosmetic formulations to improve stability and skin penetration. Used since the 1970s in anti-aging and moisturizing products.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Histidine HCl
European Commission
EU Cosmetic Ingredient Database (CosIng)
Safety and efficacy of l-histidine monohydrochloride monohydrate produced using Corynebacterium glutamicum KCCM 80179 for all animal species.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, de Lourdes Bastos M, Christensen H et al.
EFSA journal. European Food Safety Authority, 2019
Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCC
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H et al.
EFSA journal. European Food Safety Authority, 2020
Histidine HCl
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR