Hydroxy Tetramethylpiperidine Oxide
AKA “Tanol, 4-Oxypiperidol, TMPN, HyTEMPO, Nitroxyl 2, 1-Piperidinyloxy, 4-hydroxy-2, 2, 6, 6-tetramethyl-, DTXSID4041280, 4-Hydroxy-2, 6-tetramethylpiperidine 1-oxyl, MBM-02, U78ZX2F65X
Antioxidant
Ingredient Facts
Hydroxy tetramethylpiperidine oxide
AKA: Tanol, 4-Oxypiperidol, TMPN, HyTEMPO, Nitroxyl 2, 1-Piperidinyloxy, 4-hydroxy-2, 2, 6, 6-tetramethyl-, DTXSID4041280, 4-Hydroxy-2, 6-tetramethylpiperidine 1-oxyl, MBM-02, U78ZX2F65X
Antioxidant · Antioxidant · EWG: 4
Synthetic
Antioxidant
Not Clean
1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine; 1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-; 1-λ1-Oxidanyl-2,2,6,6-tetramethylpiperidin-4-ol2,2,6,6-tetramethylpiperidine-1,4-diol; 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy; 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical; 4-Hydroxy-2,2,6,6-tetramethylpiperidinoxy; 4-Hydroxy-2,2,6,6-tetramethylpiperidinoxyl; 4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINOXYL-; 4-Hydroxy-TEMPO; HTMPO; Hydroxy Tempo
Formula
C9H18NO2
Mol. Weight
172.24
CAS #
2226-96-2
Form
Powder
State
Pellets or Large Crystals; Dry Powder; Liquid; Other Solid
See origin →
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Neutralizes Free Radicals
Traditional Use
A modern synthetic antioxidant developed in the late 20th century specifically for cosmetic preservation and anti-aging formulations, with no traditional historical use.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Safety Assessment of Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol)) Citrate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Wheat Germ Oil PEG-40 Butyloctanol Esters
European Commission
EU Cosmetic Ingredient Database (CosIng)
Toluidines, their isomers, salts and halogenated and sulfonated derivatives except 4-hydroxy-2-nitro-toluidine and hydroxyethyl-2-nitro-p-toluidine
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Safety Assessment of Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol) Citrate as Used in Cosmetics.
Raj PS, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
Safety Assessment of Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol) Citrate as Used in Cosmetics.
Raj PS, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR