Hydroxypropyl Cyclodextrin
AKA “RefChem:789549
Synthetic
Ingredient Facts
Hydroxypropyl cyclodextrin
AKA: RefChem:789549
Synthetic · Humectant · EWG: 4
Synthetic
Humectant
Skin Conditioner
Synthetic
Clean
A gentle conditioning agent that helps improve skin texture and allows fragrances to blend smoothly into formulas. Derived from natural starch sources.
Formula
C39H66O31
Mol. Weight
1030.90
CAS #
128446-33-3, 128446-35-5
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Solubilising
Locks in moisture
Traditional Use
Developed in the late 20th century as a synthetic solubilizing agent derived from cyclodextrin technology. Used in cosmetics to improve the bioavailability and stability of poorly soluble active ingredients.
Skin Types
all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
Dermal absorption: 2%. Source: CIR Safety Assessment (CIR Seq 680).
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR