Isopentane
AKA “2-Methylbutane, 78-78-4, Isoamylhydride, Butane, 2-methyl-, iso-Pentane, 1, 2-Trimethylethane, Dimethylethylmethane, Ethyldimethylmethane, methylbutane”
Ingredient
Ingredient Facts
Isopentane
AKA: 2-Methylbutane, 78-78-4, Isoamylhydride, Butane, 2-methyl-, Iso-Pentane, 1, 2-Trimethylethane, Dimethylethylmethane, Ethyldimethylmethane, Methylbutane
Ingredient · Propellant · EWG: 4
Synthetic
Solvent
Not Clean
Isopentane is a hydrocarbon and one of three isomers of pentane. Pentanes are components of some fuels, such as gasoline, and are also used as specialty solvents in the laboratory. (L1287)
Solubility less than 1 mg/mL at 73 °F (NTP, 1992)
Formula
C5H12
Mol. Weight
72.15
CAS #
78-78-4
Form
Powder
State
Watery colorless liquid with a gasoline-like odor. Floats on water. Flammable, irritating vapor is produced. Boiling point is 82 °F. (USCG, 1999)
See origin →
Functions
Propellant
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Viscosity Controlling
Dispenses Product
Dissolves Ingredients
Controls Viscosity
Propels product from container
Dissolves other ingredients
Controls product thickness
Traditional Use
A synthetic hydrocarbon solvent developed in the 20th century for cosmetic formulations. Used for its volatile properties to improve product spreadability and quick-drying characteristics.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Final Report of the Safety Assessment of Isobutane, Isopentane, n-Butane, and Propane
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2-Methyl-5-Hydroxyethylaminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Isobutane, Butane, Isopentane and Propane
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
1,2-Butanediol
European Commission
EU Cosmetic Ingredient Database (CosIng)
1,4-Butanediol
European Commission
EU Cosmetic Ingredient Database (CosIng)
1,4-Butanediol/Succinic Acid/Adipic Acid/HDI Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
2-Methyl-5-Hydroxyethylaminophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
2,3-Butanediol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Bis-Hydroxyethyl Acrylate Poly(1,4-Butanediol)-9/TMHDI Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
Bis-Isostearyl 1,4-Butanediol/HDI/Hydrogenated Dimer Dilinoleyl Alcohol Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
Butane
European Commission
EU Cosmetic Ingredient Database (CosIng)
Dilinoleic Acid/Butanediol Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
Isobutane
European Commission
EU Cosmetic Ingredient Database (CosIng)
Isopentane
European Commission
EU Cosmetic Ingredient Database (CosIng)
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
1,2-Butanediol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
1,4-Butanediol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2-Methyl-1-Phenyl-2-Propanol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2-Methyl-5-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2,3-Butanediol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Butane
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Dilinoleic Acid/Butanediol Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Isobutane
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Isopentane
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
1,2-Epoxybutane
Health Canada
Health Canada Cosmetic Ingredient Hotlist
2-Methyl-m-phenylenediamine
Health Canada
Health Canada Cosmetic Ingredient Hotlist
2,3-Dichloro-2-methylbutane
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Butane
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Isobutane
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Prospects on bio-based 2,3-butanediol and acetoin production: Recent progress and advances.
Maina S, Prabhu AA, Vivek N, Vlysidis A, Koutinas A et al.
Biotechnology advances, 2022
Metabolic Engineering of Escherichia coli for De Novo Production of 1,2-Butanediol.
Qin N, Zhu F, Liu Y, Liu D, Chen Z
ACS synthetic biology, 2024
Isobutane, Isopentane, Butane, and Propane.
Tucker R, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
Isobutane, Isopentane, Butane, and Propane.
Tucker R, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
Isobutane, Isopentane, Butane, and Propane.
Tucker R, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR