Isopropyl Isostearate
AKA “Nikkol IPIS, Wickenol 131, Isooctadecanoic acid, 1-methylethyl ester, PRISORINE 2021, CRODAMOL IPIS, DERMOL IPIS, JEECHEM IPIS
Synthetic
Ingredient Facts
Isopropyl isostearate
AKA: Nikkol IPIS, Wickenol 131, Isooctadecanoic acid, 1-methylethyl ester, PRISORINE 2021, CRODAMOL IPIS, DERMOL IPIS, JEECHEM IPIS
Synthetic · Emollient · EWG: 5
Synthetic
Emollient
Skin Conditioner
Synthetic
Clean
A lightweight conditioning agent that helps lock in moisture and keeps skin and hair soft and smooth without feeling greasy.
Formula
C21H42O2
Mol. Weight
326.60
CAS #
31478-84-9, 68171-33-5
Form
Liquid
See origin →
Functions
Binder
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Holds Formula Together
Softens & Smooths
Smooths and softens skin
Holds ingredients together
Traditional Use
The CAS number for Dimethicone, a silicone polymer developed in the mid-20th century for industrial use and later adopted in cosmetics as a skin protectant and conditioning agent.
Skin Types
all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
EWG
5
CIR
Insufficient
Pregnancy
CIR Safety Findings
Not a Sensitizer
all-shades-safe
Regulatory Status
USAunder review
CANADApermitted
Regulatory Agencies
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR