Isopropyl Isostearate
AKA “68171-33-5, Nikkol IPIS, Wickenol 131, Isooctadecanoic acid, 1-methylethyl ester, PRISORINE 2021, C67IXB9Y7T, CRODAMOL IPIS, DERMOL IPIS, JEECHEM IPIS
Synthetic
Ingredient Facts
Isopropyl isostearate
AKA: 68171-33-5, Nikkol IPIS, Wickenol 131, Isooctadecanoic acid, 1-methylethyl ester, PRISORINE 2021, C67IXB9Y7T, CRODAMOL IPIS, DERMOL IPIS, JEECHEM IPIS
Synthetic · Emollient · EWG: 1
Synthetic
Emollient
Skin Conditioner
Synthetic
Clean
The CIR Expert Panel concluded that the alkyl esters, listed subsequently, are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating.
Formula
C21H42O2
Mol. Weight
326.60
CAS #
31478-84-9, 68171-33-5
Form
Liquid
See origin →
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Holds Formula Together
Softens & Smooths
Conditions Skin
Smooths and softens skin
Holds ingredients together
Traditional Use
The CAS number for Dimethicone, a silicone polymer developed in the mid-20th century for industrial use and later adopted in cosmetics as a skin protectant and conditioning agent.
Skin Types
all-skin-types
Best For
General
EWG
1
CIR
Insufficient
Pregnancy
CIR Safety Findings
Not a Sensitizer
all-shades-safe
Regulatory Status
USAunder review
CANADApermitted
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR