Isostearyl Glyceryl Ether
AKA “monoisostearyl glyceryl ether, GE-IS cpd, RefChem:149991, Penetol GE-IS, GE-IS, 78145-84-3, UNII-OWD43055HV, OWD43055HV, 1, 2-Propanediol, 3-(isooctadecyloxy)-”
Skin Conditioning
Ingredient Facts
Isostearyl glyceryl ether
AKA: Monoisostearyl glyceryl ether, GE-IS cpd, RefChem:149991, Penetol GE-IS, GE-IS, 78145-84-3, UNII-OWD43055HV, OWD43055HV, 1, 2-Propanediol, 3-(isooctadecyloxy)-
Skin Conditioning · Skin Conditioning · EWG: 1
Plant-Derived
Skin Conditioner
Plant Oil
Clean
3-Isooctadecyloxypropane-1,2-diol
Formula
C21H44O3
Mol. Weight
344.60
CAS #
78145-84-3
Form
Liquid
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
A synthetic emollient derived from isostearyl alcohol and glycerin, developed in the late 20th century. Used in cosmetics to provide hydration, slip, and skin conditioning without excessive greasiness.
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Isostearyl Glyceryl Ether
European Commission
EU Cosmetic Ingredient Database (CosIng)
Isostearyl Glyceryl Ether
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Potential application of novel liquid crystal nanoparticles of isostearyl glyceryl ether for transdermal delivery of 4-biphenyl acetic acid.
Fujii MY, Asakawa Y, Fukami T
International journal of pharmaceutics, 2020
Self-Assembled Structure of α-Isostearyl Glyceryl Ether Affects Skin Permeability-a Lamellar with 70-nm Spaces and L3 Phase Enhanced the Transdermal D
Sano T, Okada A, Kawasaki K, Kume T, Fukui M et al.
AAPS PharmSciTech, 2022
Self-Assembled Structure of α-Isostearyl Glyceryl Ether Affects Skin Permeability-a Lamellar with 70-nm Spaces and L3 Phase Enhanced the Transdermal D
Sano T, Okada A, Kawasaki K, Kume T, Fukui M et al.
AAPS PharmSciTech, 2022
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR