Leucine
AKA “L-leucine, (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid, (2S)-2-amino-4-methylpentanoic acid, Leucin, (S)-2-Amino-4-methylvaleric acid, (S)-(+)-Leucine, L-alpha-Aminoisocaproic acid
Synthetic
Ingredient Facts
Leucine
AKA: L-leucine, (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid, (2S)-2-amino-4-methylpentanoic acid, (S)-2-Amino-4-methylvaleric acid, (S)-(+)-Leucine, L-alpha-Aminoisocaproic acid
Synthetic · Antistatic · EWG: 4
Synthetic
Skin Conditioner
Hair Care
Amino Acid
Synthetic
Clean
A naturally-derived amino acid that strengthens hair and smooths skin while reducing frizz and static for a polished finish.
Effective at 0.04%
Solubility 21500
Formula
C6H13NO2
Mol. Weight
131.17
CAS #
61-90-5
Form
Powder
State
White solid; [Merck Index] White powder; [Sigma-Aldrich MSDS]
See origin →
Functions
Antistatic
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
An amino acid first isolated in 1820, part of the branched-chain amino acid group. Used in modern skincare for skin conditioning and as a humectant to improve skin hydration and appearance.
Skin Types
all-skin-types
Best For
Dryness
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
medical-approval
all-shades-safe
Concentration Guide
3e-05%
0.07%
0%100%
Effective Range
CIR reported use: 0.00009-0.05 | 0.00003-0.07 | 0.0003-0.002
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR