Leucine
AKA “L-leucine, 61-90-5, (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid, (2S)-2-amino-4-methylpentanoic acid, Leucin, (S)-2-Amino-4-methylvaleric acid, (S)-(+)-Leucine, L-alpha-Aminoisocaproic acid
Skin Conditioning
Ingredient Facts
Leucine
AKA: L-leucine, 61-90-5, (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid, (2S)-2-amino-4-methylpentanoic acid, (S)-2-Amino-4-methylvaleric acid, (S)-(+)-Leucine, L-alpha-Aminoisocaproic acid
Skin Conditioning · Antistatic · EWG: 1
Synthetic
Skin Conditioner
Hair Care
Amino Acid
Clean
Leucine (abbreviated as Leu or L)[2] is a branched-chain л±-amino acid with the chemical formulaHO2CCH(NH2)CH2CH(CH3)2. Leucine is classified as a hydrophobic amino acid due to its aliphatic isobutyl side chain. It is encoded by six codons (UUA, UUG, CUU, CUC, CUA, and CUG) and is a major component of the subunits in ferritin, astacin, and other 'buffer' proteins. Leucine is an essential amino acid, meaning that the human body cannot synthesize it, and it therefore must be ingested. It is important for hemoglobin formation.
Effective at 0.04%
Solubility 21500
Formula
C6H13NO2
Mol. Weight
131.17
CAS #
61-90-5
Form
Powder
State
White solid; [Merck Index] White powder; [Sigma-Aldrich MSDS]
See origin →
Functions
Antistatic
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
An amino acid first isolated in 1820, part of the branched-chain amino acid group. Used in modern skincare for skin conditioning and as a humectant to improve skin hydration and appearance.
Skin Types
all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
medical-approval
all-shades-safe
Concentration Guide
3e-05%
0.07%
0%100%
Effective Range
CIR reported use: 0.00009-0.05 | 0.00003-0.07 | 0.0003-0.002
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR